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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-Leprdb mice

Fig. 6

A photomicrograph example of a pancreatic section of spontaneous pre-diabetic mutant BKS-Leprdb mice after standard pellet diet, β-sitosterol compound, plant extract or positive control chlorpropamide administration for 4 weeks. The islets are variably enlarged due to hyperplasia of cells and fusion of multiple islets. Pancreatic islet cell hyperplasia is characterized by enlargement of islets (up to 500 μm in diameter). While other islets are variably small due to degeneration of cells. Pancreatic islet cell atrophy is characterized by decrease of islets (less than 50 μm in diameter). Group A: Consist of pancreatic islet cell hyperplasia (Slide A; diameter 1168.38 μm) and atrophy (Slide B and C; diameter <44.59 μm) in spontaneous pre-diabetic mutant BKS-Leprdb mice fed with standard pellet diet for 4 weeks. Group B and C: Consist of pancreatic islet cell hyperplasia (Slide D; diameter 675.20 μm) and (Slide E; diameter 540.00 μm) in spontaneous pre-diabetic mutant BKS-Leprdb mice fed with β-sitosterol compound or plant extract for 4 weeks. Group D: Consist of pancreatic islet cell hyperplasia (Slide F; large islet diameter 709.03 μm, connected to small islet diameter 220.78 μm) and few exocrine acini trapped near the periphery (Slide G) in spontaneous pre-diabetic mutant BKS-Leprdb mice fed with positive control chlorpropamide for 4 weeks. (Haematoxylin-eosin staining, 400× and 100x). Scale bars, 50 μm. Key: Black arrow- Islets of Langerhans; Red arrow- Exocrine acini

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