Skip to main content

Table 1 Cytotoxicity and anti-HIV activities of pure compounds isolated from C. macrostachyus

From: In vitro anti-HIV and cytotoxic effects of pure compounds isolated from Croton macrostachyus Hochst. Ex Delile

Tested compounds

Cytotoxicity

Antiviral activity

SI

MNTC (μg/mL)

CC50 (μg/mL)

EmaxC (%)

IC50 (μg/mL)

EmaxAV (%)

FDA Approved antiretroviral Drugs

AZT

0.38 ± 0.19

0.53 ± 0.29

36.28 ± 0.83

0.002 ± 0.00

83.5 ± 0.57

279.4

TDF

4.92 ± 0.71

6.73 ± 0.24

13.17 ± 0.43

0.04 ± 0.01

80.55 ± 0.46

176.5

ABC

0.18 ± 0.03

0.26 ± 0.00

17.83 ± 0.57

0.05 ± 0.031

58.67 ± 0.43

5.0

NVP

0.57 ± 0.0

0.82 ± 0.0

39.13 ± 0.65

0.24 ± 0.09

72.53 ± 0.47

3.5

Pure compounds isolated from C. macrostachyus

1

0.002 ± 0.00

0.001 ± 0.00

39.1 ± 2.22

0.25 ± 0.02

53.22 ± 3.345

0.0073

2

14.17 ± 0.94

28.83 ± 0.54

38.53 ± 0.69

0.002 ± 0.001

64.74 ± 0.52

14,084.0

3

16.01 ± 0.64

32.46 ± 0.7

55.91 ± 0.93

0.002 ± 0.00

75.8 ± 0.59

15,097.7

4

16.54 ± 0.35

31.74 ± 0.55

55.13 ± 0.15

0.002 ± 0.04

76.17 ± 0.02

15,551.2

5

75.75 ± 0.74

141.8 ± 0.7

70.28 ± 0.75

0.047 ± 0.02

77.01 ± 0.38

3048.2

6

4.41 ± 0.04

5.83 ± 0.20

42.74 ± 0.09

5.58 ± 0.231

84.65 ± 0.54

1.0

7

4.70 ± 3.43

12.38 ± 10.88

43.71 ± 2.02

0.14 ± 0.04

76.77 ± 23.24

86.5

  1. Results are shown as mean ± S.E.M (n = 3)
  2. AZT Zidovudine, TDF Tenofovir, ABC Abacavir, NVP Nevirapine; 2-methoxy benzyl benzoate (1); lupenone (2); lupeol acetate (3); betulin (4); lupeol (5); sitosterol (6); stigmasterol (7); MNTC Maximum nontoxic concentration, CC50 50% cytotoxic concentration, EmaxC Maximum cytotoxic effect %, IC50 50% antiviral effect concentrations, EmaxAV Maximum antiviral effect %, SI Selective index