Tested compounds | Cytotoxicity | Antiviral activity | SI | |||
---|---|---|---|---|---|---|
MNTC (μg/mL) | CC50 (μg/mL) | EmaxC (%) | IC50 (μg/mL) | EmaxAV (%) | ||
FDA Approved antiretroviral Drugs | ||||||
AZT | 0.38 ± 0.19 | 0.53 ± 0.29 | 36.28 ± 0.83 | 0.002 ± 0.00 | 83.5 ± 0.57 | 279.4 |
TDF | 4.92 ± 0.71 | 6.73 ± 0.24 | 13.17 ± 0.43 | 0.04 ± 0.01 | 80.55 ± 0.46 | 176.5 |
ABC | 0.18 ± 0.03 | 0.26 ± 0.00 | 17.83 ± 0.57 | 0.05 ± 0.031 | 58.67 ± 0.43 | 5.0 |
NVP | 0.57 ± 0.0 | 0.82 ± 0.0 | 39.13 ± 0.65 | 0.24 ± 0.09 | 72.53 ± 0.47 | 3.5 |
Pure compounds isolated from C. macrostachyus | ||||||
1 | 0.002 ± 0.00 | 0.001 ± 0.00 | 39.1 ± 2.22 | 0.25 ± 0.02 | 53.22 ± 3.345 | 0.0073 |
2 | 14.17 ± 0.94 | 28.83 ± 0.54 | 38.53 ± 0.69 | 0.002 ± 0.001 | 64.74 ± 0.52 | 14,084.0 |
3 | 16.01 ± 0.64 | 32.46 ± 0.7 | 55.91 ± 0.93 | 0.002 ± 0.00 | 75.8 ± 0.59 | 15,097.7 |
4 | 16.54 ± 0.35 | 31.74 ± 0.55 | 55.13 ± 0.15 | 0.002 ± 0.04 | 76.17 ± 0.02 | 15,551.2 |
5 | 75.75 ± 0.74 | 141.8 ± 0.7 | 70.28 ± 0.75 | 0.047 ± 0.02 | 77.01 ± 0.38 | 3048.2 |
6 | 4.41 ± 0.04 | 5.83 ± 0.20 | 42.74 ± 0.09 | 5.58 ± 0.231 | 84.65 ± 0.54 | 1.0 |
7 | 4.70 ± 3.43 | 12.38 ± 10.88 | 43.71 ± 2.02 | 0.14 ± 0.04 | 76.77 ± 23.24 | 86.5 |