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Table 1 In vitro cytotoxicity and antiprotozoal activity of menthol and its prodrugs

From: Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches

Compound

Cytotoxicity

Antiplasmodial activity

Trypanocidal activity

Leishmanicidal activity

LC50 (μΜ)a

EC50 (μΜ) b

ISc

EC50 (μΜ) b

ISc

EC50 (μΜ) b

ISc

Menthol

265.7 ± 188.1

358.5 ± 51.0

0.7

173.4 ± 28.9

1.5

 > 128.0

 > 2.1

1

68.5 ± 6.7

127.4 ± 9.9

0.5

105.45 ± 34.52

0.6

22.9 ± 2.8

3.0

2

103.3 ± 35.8

28.4 ± 0.4

3.6

33.8 ± 4.3

3.1

28.4 ± 0.4

3.6

3

57.0 ± 14.4

60.7 ± 1.2

0.9

33,83 ± 2,84

1.7

31.8 ± 4.1

1.8

4

145.2 ± 74.5

60.7 ± 1.0

2.4

2061.7 ± 175.4

0.1

43.2 ± 0.3

3.4

5

207.3 ± 38.2

56.3 ± 1.0

3.7

121.7 ± 21.4

1.7

59.3 ± 1.4

3.5

6

221,51 ± 21,07

59.1 ± 2.6

3,7

29.6 ± 1.2

7.4

96.7 ± 0.6

2,3

7

73.3 ± 15.8

432.5 ± 238.7

0.2

46.3 ± 4.9

1.6

28.2 ± 1.1

2.6

8

48.4 ± 6.1

67.4 ± 5.8

0.7

27.6 ± 4.4

1.8

 > 23.5

 > 2.1

9

44.1 ± 3.8

62.4 ± 6.5

0.7

26.7 ± 4.6

1.7

463.3 ± 205.7

0.1

DOXOd

1.7 ± 0.2

NAe

NA

NA

NA

NA

NA

CQf

485.3 ± 16.3

10.5 ± 1.3

46.2

NA

NA

NA

NA

BNZg

 > 768.5

NA

NA

60.1 ± 12.2

12.8

NA

NA

AMBh

53.9 ± 7.4

NA

NA

NA

NA

0.4 ± 0.1

134.8

  1. Data represent the lethal and effective concentration for each compound
  2. aMedian lethal concentration
  3. bMedian effective concentration
  4. cIS Index of Selectivity = LC50/EC50
  5. dDOXO Doxorubicin
  6. eNA No apply, CQ Cloroquine, BNZ Benznidazole, AMB Amphotericin B