Compound | Cytotoxicity | Antiplasmodial activity | Trypanocidal activity | Leishmanicidal activity | |||
---|---|---|---|---|---|---|---|
LC50 (μΜ)a | EC50 (μΜ) b | ISc | EC50 (μΜ) b | ISc | EC50 (μΜ) b | ISc | |
Menthol | 265.7 ± 188.1 | 358.5 ± 51.0 | 0.7 | 173.4 ± 28.9 | 1.5 |  > 128.0 |  > 2.1 |
1 | 68.5 ± 6.7 | 127.4 ± 9.9 | 0.5 | 105.45 ± 34.52 | 0.6 | 22.9 ± 2.8 | 3.0 |
2 | 103.3 ± 35.8 | 28.4 ± 0.4 | 3.6 | 33.8 ± 4.3 | 3.1 | 28.4 ± 0.4 | 3.6 |
3 | 57.0 ± 14.4 | 60.7 ± 1.2 | 0.9 | 33,83 ± 2,84 | 1.7 | 31.8 ± 4.1 | 1.8 |
4 | 145.2 ± 74.5 | 60.7 ± 1.0 | 2.4 | 2061.7 ± 175.4 | 0.1 | 43.2 ± 0.3 | 3.4 |
5 | 207.3 ± 38.2 | 56.3 ± 1.0 | 3.7 | 121.7 ± 21.4 | 1.7 | 59.3 ± 1.4 | 3.5 |
6 | 221,51 ± 21,07 | 59.1 ± 2.6 | 3,7 | 29.6 ± 1.2 | 7.4 | 96.7 ± 0.6 | 2,3 |
7 | 73.3 ± 15.8 | 432.5 ± 238.7 | 0.2 | 46.3 ± 4.9 | 1.6 | 28.2 ± 1.1 | 2.6 |
8 | 48.4 ± 6.1 | 67.4 ± 5.8 | 0.7 | 27.6 ± 4.4 | 1.8 |  > 23.5 |  > 2.1 |
9 | 44.1 ± 3.8 | 62.4 ± 6.5 | 0.7 | 26.7 ± 4.6 | 1.7 | 463.3 ± 205.7 | 0.1 |
DOXOd | 1.7 ± 0.2 | NAe | NA | NA | NA | NA | NA |
CQf | 485.3 ± 16.3 | 10.5 ± 1.3 | 46.2 | NA | NA | NA | NA |
BNZg |  > 768.5 | NA | NA | 60.1 ± 12.2 | 12.8 | NA | NA |
AMBh | 53.9 ± 7.4 | NA | NA | NA | NA | 0.4 ± 0.1 | 134.8 |