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Fig. 1 | BMC Complementary Medicine and Therapies

Fig. 1

From: Proangiogenesis effects of compound danshen dripping pills in zebrafish

Fig. 1

Screening of potential target genes andpathways of CDDP. A We obtained 7,100 coronary heart disease-related genes from GeneCards, 108 target genes of Panax notoginseng and 162 target genes of Radix Salviae from the TCMSP database. The 65 intersecting genes were considered important targets and were further studied. B Among the top 28 potential target genes predicted to be regulated by CDDP, AKT1 and JUN ranked highest. C Protein–protein interactions (PPIs) of the 65 targets (interaction score ≥ 0.950). The separated proteins were predicted to be less related and then deleted. D, E GO enrichment analysis showing the top 20 molecular biological functions of the target genes. This result demonstrated that DNA-binding transcription factor binding was the most common gene function. The abscissa represents the ratio of related genes, and the ordinate lists the functions corresponding to proteins. The bubble size represents the number of genes, whereas the color represents the P value. F, G KEGG pathway enrichment analysis showing the 20 most likely pathways involved; the PI3K-AKT signaling pathway ranked first

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