Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease

Table 3 The identified compounds and their relative abundance in top 4 active Citrus extracts

m/z (-ve ion mode)	Identified compounds name	Relative abundance (%) of metabolites in top 4 active Citrus extracts
		*C. paradisi*^a	*C. sinesis*^b	*C. aurantinum*^c	*C. reticulata*^d
215	Bergaptene	4	0	0	0
215	Gallic acid	0	8	4	0
255	Palmitic acid	34	32	0	51.5
269	Alpinetin	12	0	0	0
279	Linoleic acid	56	0	0	0
281	Octadec-12-enoic acid	33	16	0	37.5
283	Stearic acid	12	0	0	0
301	Hesperitin	18	38	12	83
301	Quercetin	0	0	88	0
331	(R)-Marmin	7	0	0	0
339	Esculin	0	7	0	10
367	Lignoceric acid	4	7	0	0
377	Galactinol dihydrate	0	0	5	0
383	Cerebronic acid	3	0	0	16
435	Methoxyflavone	3	2	0	0
459	Feruric acid di-saccharide	6	0	0	0
461	Diosmetin-7-O-glucoside	0	2	0	0
477	Isorhamnetin glucoside	0	0	5	0
535	Naringenin arabinofuranose	2	0	0	0
539	Sugar oligomers (trisaccharides and their water adducts)	0	0	3	0
579	Naringin	6	6	8	11
593	Poncirin	0	6	0	0
609	Hesperidin	100	100	100	100
610	Neohesperidin	29	36	32	32
645^e	i-Hesperidin + 2H₂O ii-Cyanidin-3-O-sophoroside chloride	20	64	41.5	66
647	Rutin adduct	8	52	17	37

^aGrapefruit mesocarp extract,^bOrange whole fruit extract,^cBitter orange whole fruit extract, and ^dMandarin whole fruit extract.^eCyanidin-3-O-sophoroside chloride is only detected in traces in C. paradisi n-hexane extract, m/z 645 predominantly belongs to the dihydrated adduct of hesperidin in all extracts

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