Metabolomic strategies and biochemical analysis of the effect of processed Rehmanniae radix extract on a blood-deficient rat model

Table 2 Compounds differing between DRR and PRR extracts, based on multivariate analysis

No.	Compound	Formula	Calculated (Da)	Detected (Da)	Error (ppm)	Related changed trend
1	5-hydroxymethyl furaldehyde	C₆H₆O₃	149.0209	149.0209	0.00	↑
2	Dihydrocatalpol	C₁₅H₂₄O₁₀	387.1262	387.1259	−0.77	↓
3	Adenosine	C₁₀H₁₃N₅O₄	268.1040	268.1035	−1.86	↓
4	Melittoside	C₂₁H₃₂O₁₅	547.1633	547.1633	0.00	↓
5	Rehmannioside D	C₂₇H₄₂O₂₀	709.2161	709.2152	−1.27	↓
6	Guaicylglycerol	C₁₀H₁₄O₅	237.0733	237.0753	−2.11	+
7	Rehmannia glutinin A	C₁₉H₃₄O₈	413.2146	413.2140	−1.45	↓
8	Pterolactam	C₅H₉NO₂	116.0706	116.0706	0.00	↓
9	Harman-3-carboxylic acid	C₁₃H₁₀N₂O₂	227.0815	227.0812	−1.32	↑
10	Echinacoside	C₃₅H₄₆O₂₀	809.2475	809.2470	−0.62	↑
11	Aucubin	C₁₅H₂₂O₉	369.1156	369.1153	−0.81	↓
12	Leonuride	C₁₅H₂₄O₉	371.1312	371.1308	−1.08	–
13	Rehmannia glutinin C	C₁₉H₃₂O₇	373.2221	373.2215	−1.61	↓
14	Catalpinoside	C₁₅H₂₂O₁₀	385.1105	385.1102	−0.78	↓
15	6-O-vanilloylajugol	C₂₃H₃₀O₁₂	521.1629	521.1634	0.96	–
16	Rehmannia glycoside	C₃₁H₄₈O₁₈	731.2733	731.2728	−0.68	↓

Note: ↓↑ represent the direction of changes in content after processing (PRR); +, − represent newly generated and absent compounds after rice wine processing (PRR sample)

ISSN: 2662-7671