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Table 12 Effects of Glucomedix® on diastolic blood pressure in hypertensive rats induced by L-NAME

From: GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome

Group/dose (mg/kg)

Time (days)

0 days

7 days

14 days

21 days

28 days

NT

75.0 ± 2.71

76.6 ± 1.62

76.4 ± 2.07

76.3 ± 2.81

75.4 ± 2.64

LN

79.9 ± 2.91

125.9 ± 1.86**

121.0 ± 1.41 **

119.3 ± 1.11 **

125.1 ± 1.57 **

LN + Enal 25

84.7 ± 0.76 *

87.6 ± 1.40 *++

86.0 ± 1.29 *++

101.3 ± 0.95 **+

94.4 ± 2.37 **++

LN + GM 250

86.6 ± 1.62*

125.7 ± 2.21**

125.4 ± 1.99 **

128.3 ± 0.76**+

117.7 ± 1.11 **+

LN + GM 500

86.9 ± 1.77*

91.0 ± 1.15*++

97.1 ± 1.07**++

108.7 ± 0.95**+

104.3 ± 0.76**++

LN + GM 1000

78.9 ± 3.08

89.6 ± 1.51*++

87.6 ± 0.98 *++

102.0 ± 1.53**+

96.3 ± 1.11 **++

  1. Values are expressed as mean ± SD. n = 7; NT = normotensive control; LN = L-NAME induced control; LN + Enal = Enalapril; LN + GM 250, LN + GM 500 and LN + GM 1000 = GlucoMedix at 250, 500 and 1000 mg/kg respectively. * p < 0.05, ** p < 0.001 compared to normotensive control group; +p < 0.05, ++p < 0.001 compared to L-NAME (LN) induced control group