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Table 1 Cytotoxicity and anti-HIV-1 effect of control drugs and extracts using the MT4 cell line

From: Cytotoxicity and anti-HIV activities of extracts of the twigs of Croton dichogamus Pax

Tested substance Cytotoxicity Anti-HIV activity SI
MNTC (µg/mL) CC50 (µg/mL) EmaxC (%) IC50 (µg/mL) EmaxAV (%)  
AZT 0.38 ± 0.19 0.53 ± 0.29 36.28 ± 0.83 0.002 ± 0.00 83.5 ± 0.57 279.4
TDF 4.92 ± 0.71 6.73 ± 0.24 13.17 ± 0.43 0.04 ± 0.01 80.55 ± 0.46 176.5
ABC 0.18 ± 0.03 0.26 ± 0.00 17.83 ± 0.57 0.05 ± 0.031 58.67 ± 0.43 5.0
NVP 0.57 ± 0.0 0.82 ± 0.0 39.13 ± 0.65 0.24 ± 0.09 72.53 ± 0.47 3.5
CDD 49.7 ± 0.61 167 ± 0.18 66.22 ± 0.18 0.03 ± 0.02 81.3 ± 0.23 5491.61
CDE 0.84 ± 0.08 0.99 ± 0.2 42.38 ± 0.95 0.55 ± 0.27 77.89 ± 0.99 1.8
CDH 0.02 ± 0.01 0.04 ± 0.02 12.24 ± 0.37 0.03 ± 0.01 77.59 ± 3.52 0.9
CDM 15.4 ± 0.45 19.58 ± 0.79 42.2 ± 0.615 0.06 ± 0.01 90.83 ± 0.18 318.5
  1. MNTC (maximum nontoxic concentration), CC50 (50% cytotoxic concentration), EmaxC (maximum cytotoxic effect %), IC50 (50% antiviral effect concentration), EmaxAV (maximum antiviral effect %), SI (selectivity index). AZT, zidovudine, ABC, abacavir, NVP, nevirapine, CDD, dichloromethane fraction, CDE, ethyl acetate fraction, CDH, hexane fraction, CDM, methanol fraction. The results are shown as the means ± S.E.M