Table 1 Cytotoxicity and anti-HIV-1 effect of control drugs and extracts using the MT4 cell line
From: Cytotoxicity and anti-HIV activities of extracts of the twigs of Croton dichogamus Pax
Tested substance | Cytotoxicity | Anti-HIV activity | SI | |||
|---|---|---|---|---|---|---|
MNTC (µg/mL) | CC50 (µg/mL) | EmaxC (%) | IC50 (µg/mL) | EmaxAV (%) | ||
AZT | 0.38 ± 0.19 | 0.53 ± 0.29 | 36.28 ± 0.83 | 0.002 ± 0.00 | 83.5 ± 0.57 | 279.4 |
TDF | 4.92 ± 0.71 | 6.73 ± 0.24 | 13.17 ± 0.43 | 0.04 ± 0.01 | 80.55 ± 0.46 | 176.5 |
ABC | 0.18 ± 0.03 | 0.26 ± 0.00 | 17.83 ± 0.57 | 0.05 ± 0.031 | 58.67 ± 0.43 | 5.0 |
NVP | 0.57 ± 0.0 | 0.82 ± 0.0 | 39.13 ± 0.65 | 0.24 ± 0.09 | 72.53 ± 0.47 | 3.5 |
CDD | 49.7 ± 0.61 | 167 ± 0.18 | 66.22 ± 0.18 | 0.03 ± 0.02 | 81.3 ± 0.23 | 5491.61 |
CDE | 0.84 ± 0.08 | 0.99 ± 0.2 | 42.38 ± 0.95 | 0.55 ± 0.27 | 77.89 ± 0.99 | 1.8 |
CDH | 0.02 ± 0.01 | 0.04 ± 0.02 | 12.24 ± 0.37 | 0.03 ± 0.01 | 77.59 ± 3.52 | 0.9 |
CDM | 15.4 ± 0.45 | 19.58 ± 0.79 | 42.2 ± 0.615 | 0.06 ± 0.01 | 90.83 ± 0.18 | 318.5 |