| Dose of black ginseng extract (mg/kg) (male; n = 10/group) | Dose of black ginseng extract (mg/kg) (female; n = 10/group) | ||||||
---|---|---|---|---|---|---|---|---|
0 | 500 | 1000 | 2000 | 0 | 500 | 1000 | 2000 | |
Hematology | ||||||||
 WBC (103/mm3) | 10.7 ± 3.5 | 10.7 ± 4.2 | 11.3 ± 2.0 | 11.1 ± 1.4 | 8.6 ± 2.6 | 10.1 ± 3.5 | 7.4 ± 2.5 | 10.3 ± 2.0 |
 RBC (106/mm3) | 7.7 ± 0.4 | 7.7 ± 0.2 | 7.8 ± 0.3 | 7.8 ± 0.3 | 7.2 ± 0.3 | 7.2 ± 0.4 | 7.2 ± 0.3 | 7.0 ± 0.4 |
 HGB (g/dl) | 15.3 ± 1.5 | 15.5 ± 0.8 | 15.5 ± 0.6 | 15.8 ± 0.5 | 14.9 ± 0.3 | 14.8 ± 0.3 | 14.5 ± 0.6 | 14.5 ± 0.8 |
 HCT (%) | 44.0 ± 1.7 | 43.9 ± 1.7 | 43.9 ± 1.3 | 44.8 ± 1.6 | 40.8 ± 1.1 | 41.1 ± 1.5 | 40.6 ± 1.3 | 40.3 ± 1.7 |
 PLT (103/mm3) | 961.0 ± 100.9 | 940.0 ± 105.5 | 954.0 ± 142.4 | 931.0 ± 50.2 | 910.0 ± 83.7 | 890.0 ± 96.8 | 984.0 ± 81.6 | 1054.0 ± 164.5 |
 MCV (fl) | 57.1 ± 2.0 | 57.1 ± 1.6 | 56.4 ± 1.5 | 57.5 ± 1.3 | 57.1 ± 2.4 | 57.4 ± 3.2 | 56.2 ± 1.8 | 57.7 ± 2.4 |
 MCH (pg) | 19.8 ± 1.9 | 20.2 ± 0.8 | 19.9 ± 0.7 | 20.3 ± 0.6 | 20.8 ± 1.0 | 20.7 ± 1.0 | 20.1 ± 0.5 | 20.8 ± 0.9 |
 MCHC (g/dl) | 34.8 ± 2.9 | 35.3 ± 0.9 | 35.3 ± 0.4 | 35.3 ± 0.5 | 36.5 ± 0.6 | 36.1 ± 0.7 | 35.7 ± 1.0 | 36.0 ± 0.5 |
 Neutrophils (%) | 10.8 ± 3.3 | 13.3 ± 4.7 | 11.5 ± 4.4 | 14.2 ± 5.4 | 11.7 ± 4.1 | 13.9 ± 6.0 | 12.4 ± 3.8 | 10.9 ± 4.1 |
 Eosinophils (%) | 0.7 ± 0.2 | 1.1 ± 0.5 | 0.8 ± 0.2 | 0.8 ± 0.3 | 1.1 ± 0.4 | 1.0 ± 0.2 | 1.0 ± 0.5 | 0.9 ± 0.3 |
 Basophils (%) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 |
 Lymphocytes (%) | 86.0 ± 3.5 | 82.6 ± 5.4 | 85.0 ± 4.3 | 81.5 ± 5.5 | 84.9 ± 4.7 | 82.6 ± 6.0 | 83.7 ± 4.9 | 86.0 ± 4.2 |
 Monocytes (%) | 1.5 ± 0.5 | 2.0 ± 0.9 | 1.6 ± 0.4 | 2.3 ± 0.4* | 1.6 ± 0.6 | 1.6 ± 0.5 | 1.9 ± 0.9 | 1.2 ± 0.3 |
 Reticulocytes (%) | 3.0 ± 0.5 | 3.2 ± 0.4 | 3.0 ± 0.4 | 3.3 ± 0.5 | 3.0 ± 0.5 | 3.0 ± 1.0 | 2.9 ± 0.2 | 4.8 ± 3.6 |
 PT (sec) | 9.6 ± 0.5 | 9.7 ± 0.4 | 9.8 ± 0.4 | 9.5 ± 0.7 | 8.6 ± 0.2 | 8.6 ± 0.3 | 8.5 ± 0.3 | 8.3 ± 0.3 |
 aPTT (sec) | 38.3 ± 5.1 | 32.1 ± 2.0* | 33.6 ± 2.0* | 32.7 ± 1.5* | 29.7 ± 2.1 | 30.5 ± 2.0 | 32.2 ± 1.6 | 31.3 ± 2.3 |
Serum biochemistry | ||||||||
 BUN (mg/dL) | 12.9 ± 1.3 | 12.6 ± 2.1 | 13.0 ± 1.8 | 13.3 ± 1.9 | 14.2 ± 2.0 | 13.6 ± 1.9 | 13.6 ± 2.5 | 14.2 ± 2.3 |
 TC (mg/dL) | 71.0 ± 9.1 | 71.0 ± 8.5 | 82.0 ± 16.1 | 72.0 ± 8.5 | 83.0 ± 14.7 | 83.0 ± 14.2 | 84.0 ± 10.0 | 81.0 ± 11.7 |
 TP (g/dL) | 5.6 ± 0.2 | 5.5 ± 0.3 | 5.6 ± 0.2 | 5.4 ± 0.3 | 5.8 ± 0.3 | 6.0 ± 0.2 | 6.0 ± 0.2 | 6.0 ± 0.3 |
 Albumin (g/dL) | 2.3 ± 0.1 | 2.2 ± 0.1 | 2.2 ± 0.1 | 2.2 ± 0.1 | 2.6 ± 0.2 | 2.7 ± 0.2 | 2.7 ± 0.2 | 2.7 ± 0.3 |
 TB (mg/dL) | 0.02 ± 0.02 | 0.03 ± 0.01 | 0.03 ± 0.01 | 0.04 ± 0.01 | 0.05 ± 0.02 | 0.05 ± 0.02 | 0.05 ± 0.01 | 0.06 ± 0.02 |
 ALP (IU/L) | 668.0 ± 98.7 | 768.0 ± 179.1 | 694.0 ± 213.1 | 792.0 ± 199.4 | 345.0 ± 110.5 | 348.0 ± 70.0 | 369.0 ± 107.3 | 334.0 ± 100.2 |
 AST (IU/L) | 105.0 ± 19.8 | 101.0 ± 18.7 | 97.0 ± 16.2 | 88.0 ± 27.0 | 90.0 ± 16.9 | 104.0 ± 43.9 | 91.0 ± 19.6 | 99.0 ± 34.3 |
 ALT (IU/L) | 38.0 ± 5.0 | 43.0 ± 6.6 | 40.0 ± 7.6 | 41.0 ± 2.3 | 34.0 ± 4.4 | 42.0 ± 13.9 | 34.0 ± 4.2 | 32.0 ± 7.5 |
 GGT (IU/L) | 0.5 ± 0.5 | 0.6 ± 0.5 | 0.6 ± 0.5 | 0.5 ± 0.5 | 0.3 ± 0.5 | 0.8 ± 0.4* | 0.8 ± 0.4* | 0.9 ± 0.3* |
 Creatinine (mg/dL) | 0.42 ± 0.04 | 0.40 ± 0.05 | 0.37 ± 0.03* | 0.37 ± 0.03* | 0.41 ± 0.04 | 0.41 ± 0.04 | 0.40 ± 0.06 | 0.38 ± 0.06 |
 TG (mg/dL) | 63.0 ± 34.0 | 67.0 ± 37.0 | 67.0 ± 39.0 | 46.0 ± 20.6 | 38.0 ± 17.0 | 34.0 ± 16.9 | 24.0 ± 10.8 | 29.0 ± 11.4 |
 Glucose (mg/L) | 154.0 ± 20.1 | 149.0 ± 20.9 | 149.0 ± 22.2 | 155.0 ± 26.9 | 161.0 ± 18.4 | 152.0 ± 15.8 | 157.0 ± 13.5 | 142.0 ± 19.9 |
 A/G ratio | 0.68 ± 0.06 | 0.67 ± 0.05 | 0.67 ± 0.05 | 0.66 ± 0.05 | 0.80 ± 0.07 | 0.79 ± 0.07 | 0.83 ± 0.07 | 0.81 ± 0.07 |
 Potassium (mEq/L) | 4.93 ± 0.20 | 4.90 ± 0.24 | 4.84 ± 0.18 | 4.79 ± 0.14 | 4.24 ± 0.23 | 4.28 ± 0.22 | 4.15 ± 0.24 | 4.13 ± 0.30 |
 Chlorine (mEq/L) | 103.8 ± 1.0 | 102.7 ± 3.7 | 103.5 ± 0.7 | 102.6 ± 2.5 | 105.3 ± 1.0 | 105.2 ± 2.2 | 105.6 ± 1.9 | 104.7 ± 1.4 |
 Sodium (mEq/L) | 144.5 ± 0.7 | 142.4 ± 4.3 | 144.2 ± 0.6 | 142.5 ± 2.8 | 143.1 ± 1.2 | 143.5 ± 2.2 | 143.4 ± 1.4 | 143.1 ± 1.3 |
 Calcium (mg/dL) | 10.2 ± 0.2 | 10.1 ± 0.5 | 10.2 ± 0.2 | 10.1 ± 0.4 | 10.0 ± 0.2 | 10.2 ± 0.3 | 10.0 ± 0.2 | 10.1 ± 0.2 |
 Phosphorus (mg/dL) | 8.4 ± 0.5 | 8.2 ± 0.5 | 8.3 ± 0.5 | 8.5 ± 0.3 | 6.6 ± 0.7 | 6.9 ± 0.7 | 6.7 ± 0.7 | 6.9 ± 0.4 |