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Table 2 Hematological and serum biochemical parameters of SD rats orally treated with black ginseng extract for 28 days

From: Efficacy and safety evaluation of black ginseng (Panax ginseng C.A. Mey.) extract (CJ EnerG): broad spectrum cytotoxic activity in human cancer cell lines and 28-day repeated oral toxicity study in Sprague-Dawley rats

 

Dose of black ginseng extract (mg/kg)

(male; n = 10/group)

Dose of black ginseng extract (mg/kg)

(female; n = 10/group)

0

500

1000

2000

0

500

1000

2000

Hematology

 WBC (103/mm3)

10.7 ± 3.5

10.7 ± 4.2

11.3 ± 2.0

11.1 ± 1.4

8.6 ± 2.6

10.1 ± 3.5

7.4 ± 2.5

10.3 ± 2.0

 RBC (106/mm3)

7.7 ± 0.4

7.7 ± 0.2

7.8 ± 0.3

7.8 ± 0.3

7.2 ± 0.3

7.2 ± 0.4

7.2 ± 0.3

7.0 ± 0.4

 HGB (g/dl)

15.3 ± 1.5

15.5 ± 0.8

15.5 ± 0.6

15.8 ± 0.5

14.9 ± 0.3

14.8 ± 0.3

14.5 ± 0.6

14.5 ± 0.8

 HCT (%)

44.0 ± 1.7

43.9 ± 1.7

43.9 ± 1.3

44.8 ± 1.6

40.8 ± 1.1

41.1 ± 1.5

40.6 ± 1.3

40.3 ± 1.7

 PLT (103/mm3)

961.0 ± 100.9

940.0 ± 105.5

954.0 ± 142.4

931.0 ± 50.2

910.0 ± 83.7

890.0 ± 96.8

984.0 ± 81.6

1054.0 ± 164.5

 MCV (fl)

57.1 ± 2.0

57.1 ± 1.6

56.4 ± 1.5

57.5 ± 1.3

57.1 ± 2.4

57.4 ± 3.2

56.2 ± 1.8

57.7 ± 2.4

 MCH (pg)

19.8 ± 1.9

20.2 ± 0.8

19.9 ± 0.7

20.3 ± 0.6

20.8 ± 1.0

20.7 ± 1.0

20.1 ± 0.5

20.8 ± 0.9

 MCHC (g/dl)

34.8 ± 2.9

35.3 ± 0.9

35.3 ± 0.4

35.3 ± 0.5

36.5 ± 0.6

36.1 ± 0.7

35.7 ± 1.0

36.0 ± 0.5

 Neutrophils (%)

10.8 ± 3.3

13.3 ± 4.7

11.5 ± 4.4

14.2 ± 5.4

11.7 ± 4.1

13.9 ± 6.0

12.4 ± 3.8

10.9 ± 4.1

 Eosinophils (%)

0.7 ± 0.2

1.1 ± 0.5

0.8 ± 0.2

0.8 ± 0.3

1.1 ± 0.4

1.0 ± 0.2

1.0 ± 0.5

0.9 ± 0.3

 Basophils (%)

0.3 ± 0.1

0.3 ± 0.1

0.2 ± 0.1

0.2 ± 0.1

0.2 ± 0.1

0.2 ± 0.1

0.2 ± 0.1

0.2 ± 0.0

 Lymphocytes (%)

86.0 ± 3.5

82.6 ± 5.4

85.0 ± 4.3

81.5 ± 5.5

84.9 ± 4.7

82.6 ± 6.0

83.7 ± 4.9

86.0 ± 4.2

 Monocytes (%)

1.5 ± 0.5

2.0 ± 0.9

1.6 ± 0.4

2.3 ± 0.4*

1.6 ± 0.6

1.6 ± 0.5

1.9 ± 0.9

1.2 ± 0.3

 Reticulocytes (%)

3.0 ± 0.5

3.2 ± 0.4

3.0 ± 0.4

3.3 ± 0.5

3.0 ± 0.5

3.0 ± 1.0

2.9 ± 0.2

4.8 ± 3.6

 PT (sec)

9.6 ± 0.5

9.7 ± 0.4

9.8 ± 0.4

9.5 ± 0.7

8.6 ± 0.2

8.6 ± 0.3

8.5 ± 0.3

8.3 ± 0.3

 aPTT (sec)

38.3 ± 5.1

32.1 ± 2.0*

33.6 ± 2.0*

32.7 ± 1.5*

29.7 ± 2.1

30.5 ± 2.0

32.2 ± 1.6

31.3 ± 2.3

Serum biochemistry

 BUN (mg/dL)

12.9 ± 1.3

12.6 ± 2.1

13.0 ± 1.8

13.3 ± 1.9

14.2 ± 2.0

13.6 ± 1.9

13.6 ± 2.5

14.2 ± 2.3

 TC (mg/dL)

71.0 ± 9.1

71.0 ± 8.5

82.0 ± 16.1

72.0 ± 8.5

83.0 ± 14.7

83.0 ± 14.2

84.0 ± 10.0

81.0 ± 11.7

 TP (g/dL)

5.6 ± 0.2

5.5 ± 0.3

5.6 ± 0.2

5.4 ± 0.3

5.8 ± 0.3

6.0 ± 0.2

6.0 ± 0.2

6.0 ± 0.3

 Albumin (g/dL)

2.3 ± 0.1

2.2 ± 0.1

2.2 ± 0.1

2.2 ± 0.1

2.6 ± 0.2

2.7 ± 0.2

2.7 ± 0.2

2.7 ± 0.3

 TB (mg/dL)

0.02 ± 0.02

0.03 ± 0.01

0.03 ± 0.01

0.04 ± 0.01

0.05 ± 0.02

0.05 ± 0.02

0.05 ± 0.01

0.06 ± 0.02

 ALP (IU/L)

668.0 ± 98.7

768.0 ± 179.1

694.0 ± 213.1

792.0 ± 199.4

345.0 ± 110.5

348.0 ± 70.0

369.0 ± 107.3

334.0 ± 100.2

 AST (IU/L)

105.0 ± 19.8

101.0 ± 18.7

97.0 ± 16.2

88.0 ± 27.0

90.0 ± 16.9

104.0 ± 43.9

91.0 ± 19.6

99.0 ± 34.3

 ALT (IU/L)

38.0 ± 5.0

43.0 ± 6.6

40.0 ± 7.6

41.0 ± 2.3

34.0 ± 4.4

42.0 ± 13.9

34.0 ± 4.2

32.0 ± 7.5

 GGT (IU/L)

0.5 ± 0.5

0.6 ± 0.5

0.6 ± 0.5

0.5 ± 0.5

0.3 ± 0.5

0.8 ± 0.4*

0.8 ± 0.4*

0.9 ± 0.3*

 Creatinine (mg/dL)

0.42 ± 0.04

0.40 ± 0.05

0.37 ± 0.03*

0.37 ± 0.03*

0.41 ± 0.04

0.41 ± 0.04

0.40 ± 0.06

0.38 ± 0.06

 TG (mg/dL)

63.0 ± 34.0

67.0 ± 37.0

67.0 ± 39.0

46.0 ± 20.6

38.0 ± 17.0

34.0 ± 16.9

24.0 ± 10.8

29.0 ± 11.4

 Glucose (mg/L)

154.0 ± 20.1

149.0 ± 20.9

149.0 ± 22.2

155.0 ± 26.9

161.0 ± 18.4

152.0 ± 15.8

157.0 ± 13.5

142.0 ± 19.9

 A/G ratio

0.68 ± 0.06

0.67 ± 0.05

0.67 ± 0.05

0.66 ± 0.05

0.80 ± 0.07

0.79 ± 0.07

0.83 ± 0.07

0.81 ± 0.07

 Potassium (mEq/L)

4.93 ± 0.20

4.90 ± 0.24

4.84 ± 0.18

4.79 ± 0.14

4.24 ± 0.23

4.28 ± 0.22

4.15 ± 0.24

4.13 ± 0.30

 Chlorine (mEq/L)

103.8 ± 1.0

102.7 ± 3.7

103.5 ± 0.7

102.6 ± 2.5

105.3 ± 1.0

105.2 ± 2.2

105.6 ± 1.9

104.7 ± 1.4

 Sodium (mEq/L)

144.5 ± 0.7

142.4 ± 4.3

144.2 ± 0.6

142.5 ± 2.8

143.1 ± 1.2

143.5 ± 2.2

143.4 ± 1.4

143.1 ± 1.3

 Calcium (mg/dL)

10.2 ± 0.2

10.1 ± 0.5

10.2 ± 0.2

10.1 ± 0.4

10.0 ± 0.2

10.2 ± 0.3

10.0 ± 0.2

10.1 ± 0.2

 Phosphorus (mg/dL)

8.4 ± 0.5

8.2 ± 0.5

8.3 ± 0.5

8.5 ± 0.3

6.6 ± 0.7

6.9 ± 0.7

6.7 ± 0.7

6.9 ± 0.4

  1. WBC White blood cells, RBC Red blood cells, Hb Hemoglobin, HCT Hematocrit, PLT Platelet, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration, PT Partial thromboplastin time, aPTT activated partial thromboplastin time, BUN Blood urea nitrogen, TC Total cholesterol, TP Total protein, TB Total bilirubin, ALP Alkaline phosphatase, AST Aspartate aminotransferase, ALT Alanine aminotransferase, GGT γ-Glutamyl Transferase, and TG Triglycerides. *; p < 0.05 by one-way ANOVA followed by post-hoc Dunnett’s t-test