Attenuation of carbohydrate metabolism and lipid profile by methanolic extract of Euphorbia helioscopia and improvement of beta cell function in a type 2 diabetic rat model

Table 2 Effect of Euphorbia helioscopia on Amylin, Leptin and Thyroid hormones

Groups	Amylin (pg/ml) p = 0.007	Leptin (ng/ml) p = 0.039	T3 (pg/ml) p = 0.019	T4 (ng/ml) p = 0.018	TSH (ng/ml) P = 0.03
NC	1736.35 ± 75.97^a	1.06 ± 0.32^ab	48.44 ± 0.47^ab	59.97 ± 13.13^ab	84.90 ± 21.38^ab
PC	2962.45 ± 213.81^c	1.81 ± .39^b	40.66 ± 6.42^a	18.94 ± 3.08^a	51.42 ± 28.63^a
SC	2075.1 ± 40.67^ab	1.425 ± 0.19^ab	54.97 ± 10.19^ab	74.55 ± 14.94^b	125.24 ± 11.71^b
EH1	2078.19 ± 55.38^ab	1.12 ± 0.05^ab	70.35 ± 5.52^ab	67.27 ± 9.38^ab	117.03 ± 4.17^ab
EH2	2317.53 ± 63.15^b	0.67 ± 0.06^a	77.35 ± 4.59^b	73.67 ± 14.11^b	123.09 ± 8.97^ab

Data are expressed as means ± standard errors of a total of 8 samples for each group. Values having different lowercase letters in a column are significantly different (P ≤ 0.05). NC, negative control group; PC, positive control group (Diabetic rats without any treatment); SC (Standard control group (Diabetic rats treated with metformin at 1 mg/kg body weight via oral lavage); EH1, Treatment group-I (Diabetic rats given methanolic extract of Euphorbia helioscopia at dose of 200 mg/Kg BW via oral lavage); EH2, Treatment group-II (Diabetic rats given methanolic extract of Euphorbia helioscopia at dose of 400 mg/Kg BW via oral lavage; T3, triiodothyronine; T4, thyroxin, TSH; thyroid stimulating hormone

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