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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes

Fig. 4

The expression levels of FoxO1 and MDR1 were positively correlated with SIRT1 in SLCs/MP cells. SLCs/MP cells treated with RPMI-1640 were used as controls. SLCs/MP cells were incubated with RPMI-1640, si-SIRT (0.1 μg/100 μl, 0.2 μg/100 μl) or SIRT1 lentivirus plasmid for 72 h. (A) Western blot analysis was performed to detect the protein levels of SIRT1 and FoxO1. (B) Analysis of protein expression. (C) SIRT1 and MDR1 mRNA levels were measured by qRT–PCR. Experiments were repeated three times and data are expressed as the means ± SD. *P < 0.05 vs. control

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