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Fig. 1 | BMC Complementary Medicine and Therapies

Fig. 1

From: Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes

Fig. 1

Effect of PNS on reversing P-gp-mediated SR in lupus mice. SRLM treated with low-dose MP is indicated as a control. SRLMs were treated with low-dose MP alone, combination high-dose MP, combination high-dose MP and PNS (50 mg/kg, 100 mg/kg), or combination TQR for 4 weeks. Then, the expression of P-gp and accumulation of Rh-123 in splenic lymphocytes and serum ANA and dsDNA levels were measured by flow cytometry and ELISA. (A, a)(B, a) SRLM treated with low-dose MP. (A, b)(B, b) SRLM treated with low-dose MP and high-dose MP. (A, c)(B, c) SRLM treated with low-dose MP, high-dose MP and PNS (50 mg/kg). (A, d)(B, d) SRLM treated with low-dose MP, high-dose MP and PNS (100 mg/kg). (A, e)(B, e) SRLM treated with low-dose MP, high-dose MP and TQR. (A, f) Analysis of P-gp expression. (B, f) Analysis of intracellular accumulation of Rh-123. (C) Analysis of serum ANA level. (D) Analysis of serum dsDNA level. Experiments were repeated three times and data are expressed as the means ± SD. *P < 0.05 vs. control. **P < 0.01 vs. control

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