Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice

Table 2 Effects of crude extract and solvent fractions of the leaf of B.abyssinica on enteropooling

Types of treatment	Weight of intestinal contents (g)	The volume of the intestinal contents (ml)	Reduction of weight of intestinal contents (%)	Reduction of volume of the intestinal contents (%)
NC	0.85 ± 0.04	0.72 ± 0.05	–––––––	–––––––
Loperamide 3 mg/kg	0.26 ± 0.04	0.18 ± 0.04	69.41	75.00
Crude extract (mg/kg)
100	0.61 ± 0.03^a2b3e3	0.50 ± 0.05^a2b3e3	28.24	30.56
200	0.48 ± 0.04^a3b2	0.37 ± 0.04^a3b1	43.53	48.61
400	0.33 ± 0.03^a3c3	0.21 ± 0.03^a3c3	61.18	70.83
AF(mg/kg)
100	0.64 ± 0.02 ^a2b3e3	0.54 ± 0.02^a2b3e2	24.71	25.00
200	0.50 ± 0.03^a3b3	0.46 ± 0.03^a3b3	41.18	36.11
400	0.35 ± 0.03^a3c3	0.31 ± 0.03^a3c2	58.82	56.94
CF(mg/kg)
100	0.67 ± 0.02 ^a1b3	0.57 ± 0.02 ^b3	21.18	20.83
200	0.66 ± 0.04^a2b3	0.55 ± 0.04^a2b3	22.35	23.61
400	0.53 ± 0.04^{a3 b3}	0.42 ± 0.04^a3b2	37.65	41.67
NHF(mg/kg)
100	0.81 ± 0.04 ^b3	0.69 ± 0.05 ^b3	4.71	4.17
200	0.79 ± 0.03 ^b3	0.68 ± 0.03 ^b3	7.06	5.56
400	0.67 ± 0.04 ^a1b3	0.53 ± 0.04^{a1 b3}	21.18	20.83

Results are expressed as mean ± SEM (n = 6); statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. ^acompared to negative control, ^bcompared to loperamide, ^ccompared to 100 mg/kg, ^dcompared to 200 mg/kg, ^ecompared to 400 mg/kg. ¹p < 0.05, ²p < 0.01, ³p < 0.001. NC negative control

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