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Table 1 Effects of crude extract and solvent fractions of the leaf of B. abyssinica on castor oil-induced diarrhea

From: Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice

Types of treatment OD (min) TNF NWF WTF (g) WWF(g) % ITFO % ID
NC 64.50 ± 2.17 9.83 ± 0.70 7.50 ± 0.56 0.62 ± 0.02 0.50 ± 0.02 –– –––-
Loperamide (3 mg/kg) 118.5 ± 4.12 5.83 ± 0.70 2.50 ± 0.42 0.31 ± 0.03 0.15 ± 0.02 40.69 66.67
Crude extract (mg/kg)
 100 76.00 ± 2.31b3e3 9.50 ± 0.76b1 6.33 ± 0.49 b3e1 0.50 ± 0.53 a1b2 0.37 ± 0.02 a2b3d1e2 3.36 15.6
 200 90.67 ± 4.40a3b3 7.17 ± 0.83 4.5 ± 0.43 a2b1 0.35 ± 0.03a3 0.21 ± 0.0a3c1 27.06 40
 400 102.33 ± 5.1a3b1c3 6.67 ± 0.71a1 2.83 ± 0.31a3c1 0.34 ± 0.01a3 0.16 ± 0.02a3c2 32.15 62.67
AF(mg/kg)
 100 80.83 ± 3.20 a1b3e2 9.50 ± 0.85b1 6.50 ± 0.50 b3e1 0.59 ± 0.02 b3e3 0.43 ± 0.03b3e3 3.36 13.33
 200 87.00 ± 2.13a2b3e1 8.00 ± 0.82 4.50 ± 0.62a2 0.55 ± 0.02 b3e2 0.35 ± 0.04 a2b3e2 18.62 40
 400 104.50 ± 5.13a3c2d1 6.83 ± 0.70 3.00 ± 0.37a3c1 0.34 ± 0.03a3c3d2 0.16 ± 0.02a3c3d2 30.52 60
CF(mg/kg)
 100 77.50 ± 3.04b3e3 9.33 ± 0.84b1 6.33 ± 0.71 b2 0.55 ± 0.04b3e1 0.37 ± 0.04 b3e2 5.09 15.6
 200 86.00 ± 2.86a2b3e1 8.67 ± 0.88 5.33 ± 0.71 b1 0.45 ± 0.05a1 0.26 ± 0.02a3 11.80 28.93
 400 105.33 ± 4.65a3c3d1 6.83 ± 0.75 3.50 ± 0.56a2 0.37 ± 0.01a3c1 0.17 ± 0.02a3c2 30.52 53.33
NHF(mg/kg)
 100 66.67 ± 2.14b3 9.33 ± 1.15 6.50 ± 0.76b1 0.58 ± 0.03b3 0.40 ± 0.03b3 5.09 13.33
 200 67.33 ± 2.42b3 8.50 ± 1.09 6.33 ± 0.99b1 0.52 ± 0.03b2 0.40 ± 0.03b3 13.53 15.6
 400 73.00 ± 2.25b3 7.50 ± 1.34 6.17 ± 1.17 0.48 ± 0.04 a1 b2 0.37 ± 0.05b2 30.52 17.33
  1. Results are expressed as mean ± SEM (n = 6); statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. aCompared to the negative control, b compared to loperamide, c compared to 100 mg/kg, d compared to 200 mg/kg, e compared to 400 mg/kg. 1p < 0.05, 2p < 0.01, 3p < 0.001.NC negative control, OTD onset of diarrhea, TNF total number of feces, NWF number of wet feces, WTF weight of total feces, WWF weight of wet feces, ITFO inhibition of total fecal output, ID inhibition of diarrhea