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Table 1 Effects of crude extract and solvent fractions of the leaf of B. abyssinica on castor oil-induced diarrhea

From: Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice

Types of treatment

OD (min)

TNF

NWF

WTF (g)

WWF(g)

% ITFO

% ID

NC

64.50 ± 2.17

9.83 ± 0.70

7.50 ± 0.56

0.62 ± 0.02

0.50 ± 0.02

––

–––-

Loperamide (3 mg/kg)

118.5 ± 4.12

5.83 ± 0.70

2.50 ± 0.42

0.31 ± 0.03

0.15 ± 0.02

40.69

66.67

Crude extract (mg/kg)

 100

76.00 ± 2.31b3e3

9.50 ± 0.76b1

6.33 ± 0.49 b3e1

0.50 ± 0.53 a1b2

0.37 ± 0.02 a2b3d1e2

3.36

15.6

 200

90.67 ± 4.40a3b3

7.17 ± 0.83

4.5 ± 0.43 a2b1

0.35 ± 0.03a3

0.21 ± 0.0a3c1

27.06

40

 400

102.33 ± 5.1a3b1c3

6.67 ± 0.71a1

2.83 ± 0.31a3c1

0.34 ± 0.01a3

0.16 ± 0.02a3c2

32.15

62.67

AF(mg/kg)

 100

80.83 ± 3.20 a1b3e2

9.50 ± 0.85b1

6.50 ± 0.50 b3e1

0.59 ± 0.02 b3e3

0.43 ± 0.03b3e3

3.36

13.33

 200

87.00 ± 2.13a2b3e1

8.00 ± 0.82

4.50 ± 0.62a2

0.55 ± 0.02 b3e2

0.35 ± 0.04 a2b3e2

18.62

40

 400

104.50 ± 5.13a3c2d1

6.83 ± 0.70

3.00 ± 0.37a3c1

0.34 ± 0.03a3c3d2

0.16 ± 0.02a3c3d2

30.52

60

CF(mg/kg)

 100

77.50 ± 3.04b3e3

9.33 ± 0.84b1

6.33 ± 0.71 b2

0.55 ± 0.04b3e1

0.37 ± 0.04 b3e2

5.09

15.6

 200

86.00 ± 2.86a2b3e1

8.67 ± 0.88

5.33 ± 0.71 b1

0.45 ± 0.05a1

0.26 ± 0.02a3

11.80

28.93

 400

105.33 ± 4.65a3c3d1

6.83 ± 0.75

3.50 ± 0.56a2

0.37 ± 0.01a3c1

0.17 ± 0.02a3c2

30.52

53.33

NHF(mg/kg)

 100

66.67 ± 2.14b3

9.33 ± 1.15

6.50 ± 0.76b1

0.58 ± 0.03b3

0.40 ± 0.03b3

5.09

13.33

 200

67.33 ± 2.42b3

8.50 ± 1.09

6.33 ± 0.99b1

0.52 ± 0.03b2

0.40 ± 0.03b3

13.53

15.6

 400

73.00 ± 2.25b3

7.50 ± 1.34

6.17 ± 1.17

0.48 ± 0.04 a1 b2

0.37 ± 0.05b2

30.52

17.33

  1. Results are expressed as mean ± SEM (n = 6); statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. aCompared to the negative control, b compared to loperamide, c compared to 100 mg/kg, d compared to 200 mg/kg, e compared to 400 mg/kg. 1p < 0.05, 2p < 0.01, 3p < 0.001.NC negative control, OTD onset of diarrhea, TNF total number of feces, NWF number of wet feces, WTF weight of total feces, WWF weight of wet feces, ITFO inhibition of total fecal output, ID inhibition of diarrhea