Oral administration of tartrazine (E102) accelerates the incidence and the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced breast cancer in rats

Table 2 Effects of tartrazine and the natural dye (COL) on body mass and the relative weight of some organs

	NOR	NOR+ TARZ	DMBA	DMBA + TARZ	DMBA + COL
Body weight (g)
Initial	135.5 ± 6.7	129.8 ± 5.4	121.7 ± 6.9	124.4 ± 4.6	126.4 ± 11.9
Final	203.5 ± 6.1	195.4 ± 2.9	179.6 ± 4.2#	182.4 ± 9.6#	182.8 ± 8.2#
Organ weight (%)
Uterus	0.23 ± 0.03	0.27 ± 0.05	0.36 ± 0.05	0.25 ± 0.01	0.25 ± 0.04
Liver	2.98 ± 0.1	2.96 ± 0.15	3.19 ± 0.17	3.04 ± 0.13	2.84 ± 0.11
Lung	0.6 ± 0.07	0.58 ± 0.06	0.79 ± 0.07#	0.67 ± 0.06	0.60 ± 0.03*
Spleen	0.24 ± 0.01	0.22 ± 0.01	0.42 ± 0.04###	0.28 ± 0.006***	0.29 ± 0.03**
Adrenals	0.03 ± 0.003	0.04 ± 0.004	0.03 ± 0.009	0.02 ± 0.006	0.03 ± 0.003
Kidney	0.54 ± 0.03	0.53 ± 0.01	0.60 ± 0.02#	0.61 ± 0.01	0.59 ± 0.02
Femur	0.4 ± 0.01	0.25 ± 0.01	0.27 ± 0.06	0.26 ± 0.01	0.37 ± 0.03
Brain	0.62 ± 0.01	0.73 ± 0.02	0.77 ± 0.17	0.87 ± 0.063	0.54 ± 0.2
Ovaries	0.07 ± 0.004	0.08 ± 0.01	0.08 ± 0.01	0.067 ± 0.01	0.06 ± 0.01

NOR Animals serving as normal control receiving distilled water, NOR + TARZ Animals receiving tartrazine only, DMBA Animals serving as negative control receiving distilled water, DMBA + TARZ Animals receiving tartrazine at a dose of 50 mg/kg, DMBA + COL Animals receiving a natural dye at a dose of 50 mg/kg. #p < 0.05; ### p < 0.001 compared to the NOR group; *p < 0.05; **p < 0.01; ***p < 0.001 compared to the DMBA group

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