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Table 2 Experimental Design and Results of Box-Behnken

From: Optimization for ultrasonic-microwave synergetic extraction of total iridoid glycosides and screening of analgesic and anti-inflammatory active fractions from patrinia scabra Bunge (Valerianaceae)

Number

A

B

C

D

Y

1

−1

0

1

0

75.44

2

0

0

0

0

80.38

3

0

1

−1

0

74.02

4

0

−1

0

1

70.38

5

0

0

1

1

80.13

6

0

0

−1

1

79.46

7

0

−1

0

−1

70.11

8

0

−1

1

0

69.73

9

0

0

0

0

80.58

10

0

0

0

0

80.72

11

−1

0

0

1

75.98

12

0

−1

−1

0

69.05

13

1

1

0

0

72.49

14

0

0

1

−1

79.68

15

1

0

0

1

78.85

16

−1

1

0

0

70.73

17

0

0

0

0

81.07

18

1

0

−1

0

77.74

19

0

1

1

0

74.47

20

−1

0

0

− 1

76.28

21

1

0

0

−1

77.55

22

1

−1

0

0

67.77

23

1

0

1

0

77.17

24

0

0

−1

−1

79.03

25

−1

−1

0

0

65.66

26

−1

0

−1

0

75.05

27

0

0

0

0

80.87

28

0

1

0

-1

74.73

29

0

1

0

1

74.91

  1. Note: A ethanol concentration (%), B material-to-liquid ratio (g/mL), C microwave power (W), D extraction time (min), Y content of total iridoid glycosides (mg/g)