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Table 8 Prediction of the main pharmacokinetics parameters for curcumin, trans-resveratrol, quercetin and (1 s,4 s)-eucalyptol. These include gastrointestinal absorption, blood-brain barrier (BBB) penetration, effect on permeability glycoprotein (P-gp) and cytochromes P450 (CYP) major isoenzymes and skin permeation (log Kp)

From: Interactions of selected cardiovascular active natural compounds with CXCR4 and CXCR7 receptors: a molecular docking, molecular dynamics, and pharmacokinetic/toxicity prediction study

 

Curcumin

Trans-resveratrol

Quercetin

(1 s,4 s)-Eucalyptol

GI absorption

High

High

High

High

Blood-brain barrier (BBB) permeant

No

Yes

No

Yes

P-gp substrate

No

No

No

No

CYP1A2 inhibitor

No

Yes

Yes

No

CYP2C19 inhibitor

No

No

No

No

CYP2C9 inhibitor

Yes

Yes

No

No

CYP2D6 inhibitor

No

No

Yes

No

CYP3A4 inhibitor

Yes

Yes

Yes

No

Log Kp (skin permeation)

−6.28 cm/s

−5.47 cm/s

−7.05 cm/s

− 5.30 cm/s