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Table 6 Effect of test compounds during yeast induced hyperpyrexia in rats

From: An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Treatment Groups Dose mg/kg Basal Temperature(°C) Rectal Temperature (°C) 18 h after yeast induced pyrexia Rectal temperature (°C) after treatment with extract
1 h 2 h 3 h 4 h
DMSO G1 (10 ml/kg) 38.07 ± 0.22 38.8 ± 0.29 39.83 ± 0.105 41.067 ± 0.301 41.78 ± 0.22 42.23 ± 0.15
Ibuprofen G2 100 37.4 ± 0.20 38.3 ± 0.20 38.23 ± 0.084** 38.650 ± 0.123** 37.93 ± 0.191*** 37.53 ± 0.105***
3 G3 25 38.58 ± 0.24 39.8 ± 0.10 39.13 ± 0.092* 39.15 ± 0.089** 38.71 ± 0.083** 38.87 ± 0.084**
G4 50 38.6 ± 0.083 39.3 ± 0.059 38.41 ± 0.105** 38.76 ± 0.115** 38.283 ± 0.122*** 38.46 ± 0.080**
G5 75 37.8 ± 0.28 38.9 ± 0.084 38.28 ± 0.083** 38.43 ± 0.154** 37.93 ± 0.115*** 38.1 ± 0.124***
5 G6 50 37.7 ± 0.26 39.6 ± 0.09 38.483 ± 0.07** 37.78 ± 0.224*** 37.76 ± 0.249*** 37.98 ± 0.185***
G7 75 37.6 ± 0.161 38.4 ± 0.08 38.150 ± 0.106** 37.65 ± 0.161*** 37.5 ± 0.14*** 37.68 ± 0.117***
G8 100 37.4 ± 0.22 38.6 ± 0.121 38.067 ± 0.076** 37.5 ± 0.161*** 37.1 ± 0.103*** 37.567 ± 0.161***
  1. G Group
  2. *Significant inhibition of pyrexia (P < 0.05)
  3. **Very Significant inhibition of pyrexia (P < 0.01)
  4. ***Highly Significant inhibition of pyrexia (P < 0.001)