An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Table 6 Effect of test compounds during yeast induced hyperpyrexia in rats

Treatment	Groups	Dose mg/kg	Basal Temperature(°C)	Rectal Temperature (°C) 18 h after yeast induced pyrexia	Rectal temperature (°C) after treatment with extract
Treatment	Groups	Dose mg/kg	Basal Temperature(°C)	Rectal Temperature (°C) 18 h after yeast induced pyrexia	1 h	2 h	3 h	4 h
DMSO	G1	(10 ml/kg)	38.07 ± 0.22	38.8 ± 0.29	39.83 ± 0.105	41.067 ± 0.301	41.78 ± 0.22	42.23 ± 0.15
Ibuprofen	G2	100	37.4 ± 0.20	38.3 ± 0.20	38.23 ± 0.084**	38.650 ± 0.123**	37.93 ± 0.191***	37.53 ± 0.105***
3	G3	25	38.58 ± 0.24	39.8 ± 0.10	39.13 ± 0.092*	39.15 ± 0.089**	38.71 ± 0.083**	38.87 ± 0.084**
	G4	50	38.6 ± 0.083	39.3 ± 0.059	38.41 ± 0.105**	38.76 ± 0.115**	38.283 ± 0.122***	38.46 ± 0.080**
	G5	75	37.8 ± 0.28	38.9 ± 0.084	38.28 ± 0.083**	38.43 ± 0.154**	37.93 ± 0.115***	38.1 ± 0.124***
5	G6	50	37.7 ± 0.26	39.6 ± 0.09	38.483 ± 0.07**	37.78 ± 0.224***	37.76 ± 0.249***	37.98 ± 0.185***
	G7	75	37.6 ± 0.161	38.4 ± 0.08	38.150 ± 0.106**	37.65 ± 0.161***	37.5 ± 0.14***	37.68 ± 0.117***
	G8	100	37.4 ± 0.22	38.6 ± 0.121	38.067 ± 0.076**	37.5 ± 0.161***	37.1 ± 0.103***	37.567 ± 0.161***

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