|
Groups
|
Dose (mg/kg)
|
Licking time (sec)
|
% age Inhibition
|
|---|
|
1st Phase
|
2nd Phase
|
1st Phase
|
2nd Phase
|
|---|
|
3
|
25
|
128.8 ± 3.609*
|
572.5 ± 4.603*
|
18%
|
25%
|
|
50
|
108 ± 5.538**
|
291.1 ± 2.482***
|
31%
|
62%
|
|
75
|
94.83 ± 2.91**
|
187.6 ± 3.756***
|
39%
|
75%
|
|
5
|
50
|
135.1 ± 4.262*
|
545.8 ± 10.59*
|
14%
|
28%
|
|
75
|
125.3 ± 3.71*
|
394.83 ± 12.3**
|
20%
|
48%
|
|
100
|
100.6 ± 5.998**
|
287 ± 2.236***
|
36%
|
62%
|
|
Ibuprofen
|
100
|
126.5 ± 4.137*
|
274.8 ± 3.02***
|
19%
|
64%
|
|
DMSO(10 ml/kg)
| |
156.83 ± 4.46
|
761.1 ± 13.7
|
0
|
0
|
- %age inhibition of nociceptive response in mice, Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, (n = 6)
- *Significant inhibition of nociceptive response (P < 0.05)
- **Very significant inhibition of nociceptive response (P < 0.01)
- ***Highly significant inhibition of nociceptive response (P < 0.001)
