Skip to main content

Table 5 Analgesic effect of synthetic test compounds during formalin-induced nociception in mice

From: An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Groups Dose (mg/kg) Licking time (sec) % age Inhibition
1st Phase 2nd Phase 1st Phase 2nd Phase
3 25 128.8 ± 3.609* 572.5 ± 4.603* 18% 25%
50 108 ± 5.538** 291.1 ± 2.482*** 31% 62%
75 94.83 ± 2.91** 187.6 ± 3.756*** 39% 75%
5 50 135.1 ± 4.262* 545.8 ± 10.59* 14% 28%
75 125.3 ± 3.71* 394.83 ± 12.3** 20% 48%
100 100.6 ± 5.998** 287 ± 2.236*** 36% 62%
Ibuprofen 100 126.5 ± 4.137* 274.8 ± 3.02*** 19% 64%
DMSO(10 ml/kg)   156.83 ± 4.46 761.1 ± 13.7 0 0
  1. %age inhibition of nociceptive response in mice, Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, (n = 6)
  2. *Significant inhibition of nociceptive response (P < 0.05)
  3. **Very significant inhibition of nociceptive response (P < 0.01)
  4. ***Highly significant inhibition of nociceptive response (P < 0.001)