An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Table 5 Analgesic effect of synthetic test compounds during formalin-induced nociception in mice

Groups	Dose (mg/kg)	Licking time (sec)		% age Inhibition
Groups	Dose (mg/kg)	1st Phase	2nd Phase	1st Phase	2nd Phase
3	25	128.8 ± 3.609*	572.5 ± 4.603*	18%	25%
	50	108 ± 5.538**	291.1 ± 2.482***	31%	62%
	75	94.83 ± 2.91**	187.6 ± 3.756***	39%	75%
5	50	135.1 ± 4.262*	545.8 ± 10.59*	14%	28%
	75	125.3 ± 3.71*	394.83 ± 12.3**	20%	48%
	100	100.6 ± 5.998**	287 ± 2.236***	36%	62%
Ibuprofen	100	126.5 ± 4.137*	274.8 ± 3.02***	19%	64%
DMSO(10 ml/kg)		156.83 ± 4.46	761.1 ± 13.7	0	0

%age inhibition of nociceptive response in mice, Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, (n = 6)
^*Significant inhibition of nociceptive response (P < 0.05)
^**Very significant inhibition of nociceptive response (P < 0.01)
^***Highly significant inhibition of nociceptive response (P < 0.001)

ISSN: 2662-7671