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Table 3 Data of Acetic acid-induced wriths in mice

From: An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Treatments Doses mg/kg (i.p) No of wriths % age inhibition
3 25 38.33 ± 2.679** 53%
50 27.66 ± 1.80*** 66.83%
75 14.0 ± 0.856*** 83%
5 50 47.66 ± 2.90* 41.83%
75 36.66 ± 1.978** 55.30%
100 24.83 ± 1.759*** 70%
Ibuprofen 100 23.5 ± 1.05*** 71.5%
DMSO(10 ml/kg)   83.33 ± 3.37 0
  1. % age inhibition of wriths in mice in all groups showing analgesic activity of synthetic test compounds. Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, n = 6
  2. *Significant inhibition of nociceptive response (P < 0.05)
  3. **very significant inhibition of nociceptive response (P < 0.01)
  4. ***Highly significant inhibition of nociceptive response (P < 0.001)