|
Treatments
|
Doses mg/kg (i.p)
|
No of wriths
|
% age inhibition
|
|---|
|
3
|
25
|
38.33 ± 2.679**
|
53%
|
|
50
|
27.66 ± 1.80***
|
66.83%
|
|
75
|
14.0 ± 0.856***
|
83%
|
|
5
|
50
|
47.66 ± 2.90*
|
41.83%
|
|
75
|
36.66 ± 1.978**
|
55.30%
|
|
100
|
24.83 ± 1.759***
|
70%
|
|
Ibuprofen
|
100
|
23.5 ± 1.05***
|
71.5%
|
|
DMSO(10 ml/kg)
| |
83.33 ± 3.37
|
0
|
- % age inhibition of wriths in mice in all groups showing analgesic activity of synthetic test compounds. Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, n = 6
- *Significant inhibition of nociceptive response (P < 0.05)
- **very significant inhibition of nociceptive response (P < 0.01)
- ***Highly significant inhibition of nociceptive response (P < 0.001)
