An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Table 3 Data of Acetic acid-induced wriths in mice

Treatments	Doses mg/kg (i.p)	No of wriths	% age inhibition
3	25	38.33 ± 2.679**	53%
	50	27.66 ± 1.80***	66.83%
	75	14.0 ± 0.856***	83%
5	50	47.66 ± 2.90*	41.83%
	75	36.66 ± 1.978**	55.30%
	100	24.83 ± 1.759***	70%
Ibuprofen	100	23.5 ± 1.05***	71.5%
DMSO(10 ml/kg)		83.33 ± 3.37	0

% age inhibition of wriths in mice in all groups showing analgesic activity of synthetic test compounds. Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, n = 6
^*Significant inhibition of nociceptive response (P < 0.05)
^**very significant inhibition of nociceptive response (P < 0.01)
^***Highly significant inhibition of nociceptive response (P < 0.001)

ISSN: 2662-7671