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Table 2 Anti-inflammatory effect of test compounds in egg albumin- induced paw edema

From: An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Groups Treatments Dose mg/kg Paw edema at different time intervals %age inhibition of edema
1 h 2 h 3 h 1 h 2 h 3 h
1 DMSO 10 ml/kg 1.267 ± 0.02 1.417 ± 0.031 1.640 ± 0.040 0 0 0
2 Ibuprofen 100 0.617 ± 0.048** 0.433 ± 0.067*** 0.367 ± 0.033*** 51% 69% 78%
3 3 25 0.733 ± 0.067* 0.583 ± 0.07** 0.583 ± 0.070*** 42% 59% 64%
4 50 0.567 ± 0.049** 0.45 ± 0.043*** 0.45 ± 0.050*** 55% 68% 72%
5 75 0.383 ± 0.031*** 0.3 ± 0.037*** 0.250 ± 0.022*** 70% 79% 85%
6 5 50 0.783 ± 0.03* 0.650 ± 0.076** 0.533 ± 0.056*** 38% 54% 67%
7 75 0.5 ± 0.04** 0.5 ± 0.037*** 0.483 ± 0.054*** 60% 65% 70%
8 100 0.417 ± 0.065*** 0.417 ± 0.031*** 0.317 ± 0.031*** 67% 71% 81%
  1. Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
  2. *significant inhibition of paw edema (P < 0.05)
  3. **Very significant inhibition of paw edema (P < 0.01)
  4. ***highly significant inhibition of paw edema (P < 0.001)