An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Table 2 Anti-inflammatory effect of test compounds in egg albumin- induced paw edema

Groups	Treatments	Dose mg/kg	Paw edema at different time intervals			%age inhibition of edema
Groups	Treatments	Dose mg/kg	1 h	2 h	3 h	1 h	2 h	3 h
1	DMSO	10 ml/kg	1.267 ± 0.02	1.417 ± 0.031	1.640 ± 0.040	0	0	0
2	Ibuprofen	100	0.617 ± 0.048**	0.433 ± 0.067***	0.367 ± 0.033***	51%	69%	78%
3	3	25	0.733 ± 0.067*	0.583 ± 0.07**	0.583 ± 0.070***	42%	59%	64%
4		50	0.567 ± 0.049**	0.45 ± 0.043***	0.45 ± 0.050***	55%	68%	72%
5		75	0.383 ± 0.031***	0.3 ± 0.037***	0.250 ± 0.022***	70%	79%	85%
6	5	50	0.783 ± 0.03*	0.650 ± 0.076**	0.533 ± 0.056***	38%	54%	67%
7		75	0.5 ± 0.04**	0.5 ± 0.037***	0.483 ± 0.054***	60%	65%	70%
8		100	0.417 ± 0.065***	0.417 ± 0.031***	0.317 ± 0.031***	67%	71%	81%

Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
^*significant inhibition of paw edema (P < 0.05)
^**Very significant inhibition of paw edema (P < 0.01)
^***highly significant inhibition of paw edema (P < 0.001)

ISSN: 2662-7671