|
Groups
|
Treatments
|
Dose mg/kg
|
Paw edema at different time intervals
|
%age inhibition of edema
|
|---|
|
1 h
|
2 h
|
3 h
|
1 h
|
2 h
|
3 h
|
|---|
|
1
|
DMSO
|
10 ml/kg
|
1.267 ± 0.02
|
1.417 ± 0.031
|
1.640 ± 0.040
|
0
|
0
|
0
|
|
2
|
Ibuprofen
|
100
|
0.617 ± 0.048**
|
0.433 ± 0.067***
|
0.367 ± 0.033***
|
51%
|
69%
|
78%
|
|
3
|
3
|
25
|
0.733 ± 0.067*
|
0.583 ± 0.07**
|
0.583 ± 0.070***
|
42%
|
59%
|
64%
|
|
4
|
50
|
0.567 ± 0.049**
|
0.45 ± 0.043***
|
0.45 ± 0.050***
|
55%
|
68%
|
72%
|
|
5
|
75
|
0.383 ± 0.031***
|
0.3 ± 0.037***
|
0.250 ± 0.022***
|
70%
|
79%
|
85%
|
|
6
|
5
|
50
|
0.783 ± 0.03*
|
0.650 ± 0.076**
|
0.533 ± 0.056***
|
38%
|
54%
|
67%
|
|
7
|
75
|
0.5 ± 0.04**
|
0.5 ± 0.037***
|
0.483 ± 0.054***
|
60%
|
65%
|
70%
|
|
8
|
100
|
0.417 ± 0.065***
|
0.417 ± 0.031***
|
0.317 ± 0.031***
|
67%
|
71%
|
81%
|
- Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
- *significant inhibition of paw edema (P < 0.05)
- **Very significant inhibition of paw edema (P < 0.01)
- ***highly significant inhibition of paw edema (P < 0.001)
