|
Groups
|
Treatments
|
Dose mg/kg
|
Paw edema in mm at different time intervals
|
% age inhibition of edema
|
|---|
|
1 h
|
2 h
|
3 h
|
1 h
|
2 h
|
3 h
|
|---|
|
1
|
DMSO
|
10 ml
|
1.3 ± 0.026
|
1.467 ± 0.056
|
1.6 ± 0.039
|
0
|
0
|
0
|
|
2
|
Ibuprofen
|
100
|
0.55 ± 0.043**
|
0.450 ± 0.043***
|
0.283 ± 0.031***
|
57%
|
69%
|
82%
|
|
3
|
3
|
25
|
0.7 ± 0.037*
|
0.633 ± 0.061**
|
0.483 ± 0.048***
|
46%
|
57%
|
70%
|
|
4
|
50
|
0.517 ± 0.048**
|
0.433 ± 0.049***
|
0.317 ± 0.031***
|
60%
|
71%
|
80%
|
|
5
|
75
|
0.417 ± 0.04***
|
0.33 ± 0.033***
|
0.15 ± 0.022***
|
68%
|
77%
|
91%
|
|
6
|
5
|
50
|
0.733 ± 0.049*
|
0.6 ± 0.037**
|
0.567 ± 0.056***
|
43%
|
59%
|
65%
|
|
7
|
75
|
0.55 ± 0.043**
|
0.45 ± 0.043***
|
0.467 ± 0.033***
|
57%
|
69%
|
71%
|
|
8
|
100
|
0.45 ± 0.043***
|
0.317 ± 0.031***
|
0.3 ± 0.037***
|
66%
|
78%
|
81%
|
- Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
- *significant inhibition of paw edema (P < 0.05)
- **Very significant inhibition of paw edema (P < 0.01)
- ***Highly significant inhibition of paw edema (P < 0.001)
