An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Table 1 Anti-inflammatory effect of test compound during Carrageenan- induced paw edema in mice

Groups	Treatments	Dose mg/kg	Paw edema in mm at different time intervals			% age inhibition of edema
Groups	Treatments	Dose mg/kg	1 h	2 h	3 h	1 h	2 h	3 h
1	DMSO	10 ml	1.3 ± 0.026	1.467 ± 0.056	1.6 ± 0.039	0	0	0
2	Ibuprofen	100	0.55 ± 0.043**	0.450 ± 0.043***	0.283 ± 0.031***	57%	69%	82%
3	3	25	0.7 ± 0.037*	0.633 ± 0.061**	0.483 ± 0.048***	46%	57%	70%
4		50	0.517 ± 0.048**	0.433 ± 0.049***	0.317 ± 0.031***	60%	71%	80%
5		75	0.417 ± 0.04***	0.33 ± 0.033***	0.15 ± 0.022***	68%	77%	91%
6	5	50	0.733 ± 0.049*	0.6 ± 0.037**	0.567 ± 0.056***	43%	59%	65%
7		75	0.55 ± 0.043**	0.45 ± 0.043***	0.467 ± 0.033***	57%	69%	71%
8		100	0.45 ± 0.043***	0.317 ± 0.031***	0.3 ± 0.037***	66%	78%	81%

Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
^*significant inhibition of paw edema (P < 0.05)
^**Very significant inhibition of paw edema (P < 0.01)
^***Highly significant inhibition of paw edema (P < 0.001)

ISSN: 2662-7671