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Table 1 Anti-inflammatory effect of test compound during Carrageenan- induced paw edema in mice

From: An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Groups Treatments Dose mg/kg Paw edema in mm at different time intervals % age inhibition of edema
1 h 2 h 3 h 1 h 2 h 3 h
1 DMSO 10 ml 1.3 ± 0.026 1.467 ± 0.056 1.6 ± 0.039 0 0 0
2 Ibuprofen 100 0.55 ± 0.043** 0.450 ± 0.043*** 0.283 ± 0.031*** 57% 69% 82%
3 3 25 0.7 ± 0.037* 0.633 ± 0.061** 0.483 ± 0.048*** 46% 57% 70%
4 50 0.517 ± 0.048** 0.433 ± 0.049*** 0.317 ± 0.031*** 60% 71% 80%
5 75 0.417 ± 0.04*** 0.33 ± 0.033*** 0.15 ± 0.022*** 68% 77% 91%
6 5 50 0.733 ± 0.049* 0.6 ± 0.037** 0.567 ± 0.056*** 43% 59% 65%
7 75 0.55 ± 0.043** 0.45 ± 0.043*** 0.467 ± 0.033*** 57% 69% 71%
8 100 0.45 ± 0.043*** 0.317 ± 0.031*** 0.3 ± 0.037*** 66% 78% 81%
  1. Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
  2. *significant inhibition of paw edema (P < 0.05)
  3. **Very significant inhibition of paw edema (P < 0.01)
  4. ***Highly significant inhibition of paw edema (P < 0.001)