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Table 3 Hematological profile of rats treated with A. vera for 28 days

From: Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats

Hematological parameters

Control group

A. vera whole leaf extract dose levels in mg/kg

A. vera green rind extract dose levels in mg/kg

200

400

800

200

400

800

Combined male and female

 WBC (× 109/L)

11.8 ± 1.24

11.6 ± 1.18

13.1 ± 2.60

13.1 ± 0.57

9.9 ± 1.06

9.9 ± 1.53

12.0 ± 1.6

 NEU (× 109/L)

2.3 ± 0.40

3.0 ± 0.54

3.2 ± 0.79

2.3 ± 0.19

2.3 ± 0.29

2.4 ± 0.46

2.9 ± 0.33

 LYM(× 109/L)

8.3 ± 1.14

7.2 ± 0.89

8.4 ± 1.89

9.4 ± 0.50

6.4 ± 1.02

6.4 ± 0.92

7.7 ± 1.45

 MONO (× 109/L)

0.8 ± 0.17

0.7 ± 0.09

1.0 ± 0.21

0.8 ± 0.11

0.7 ± 0.08

0.6 ± 0.17

0.8 ± 0.14

 EOS (× 109/L)

0.27 ± 0.06

0.64 ± 0.09**

0.43 ± 0.09

0.49 ± 0.08

0.4 ± 0.06

0.4 ± 0.15

0.5 ± 0.06

 BASO (× 109/L)

0.002 ± 0.002

0.0 ± 0.00

0.0 ± 0.00

0.0 ± 0.00

0.0 ± 0.00

0.0 ± 0.00

0.0 ± 0.00

 RBC (× 1012/L)

7.7 ± 0.50

8.4 ± 0.35

8.6 ± 0.16

8.8 ± 0.37

8.6 ± 0.23

8.7 ± 0.37

8.7 ± 0.23

 Hb (g/dL)

13.7 ± 0.81

14.5 ± 0.68

15.0 ± 0.21

15.4 ± 0.37

15.3 ± 0.38

15.2 ± 0.56

15.6 ± 0.34

 HCT (%)

41.0 ± 2.71

46.0 ± 2.25

46.2 ± 0.81

47.62 ± 1.03

48.97 ± 0.80**

48.70 ± 1.56**

48.33 ± 1.30**

 MCV (fL)

53.12 ± 1.23

54.73 ± 1.15

53.73 ± 1.03

54.12 ± 1.43

56.87 ± 0.72

56.10 ± 1.62

55.12 ± 0.40

 MCH (pg)

17.82 ± 0.26

17.38 ± 0.23

17.55 ± 0.18

17.53 ± 0.33

17.78 ± 0.09

17.50 ± 0.35

17.88 ± 0.11

 MCHC (g/dL)

33.58 ± 0.42

31.73 ± 0.33**

32.68 ± 0.30

32.45 ± 0.37

31.30 ± 0.37**

31.30 ± 0.40**

32.47 ± 0.21

 RDW-CV (%)

19.22 ± 1.33

19.68 ± 0.58

20.22 ± 0.35

20.35 ± 0.72

19.28 ± 0.25

19.48 ± 0.83

19.93 ± 0.87

 PLT(× 109/L)

886.80 ± 143.80

732.0 ± 24.7

766.0 ± 49.0

742.7 ± 24.7

743.7 ± 46.53

774.0 ± 26.41

807.3 ± 68.63

Females

 WBC (× 109/L)

10.72 ± 3.11

12.56 ± 1.02

14.28 ± 5.23

12.63 ± 1.05

10.98 ± 1.87

8.42 ± 1.23

10.48 ± 0.77

 NEU (× 109/L)

1.74 ± 0.14

2.32 ± 0.13

2.90 ± 0.77

2.36 ± 0.29

2.19 ± 0.16

1.87 ± 0.45

2.36 ± 0.13

 LYM (× 109/L)

9.32 ± 1.77

8.73 ± 0.72

9.63 ± 4.00

9.11 ± 1.05

7.58 ± 1.74

5.79 ± 0.66

6.77 ± 0.70

 MONO (× 109/L)

0.83 ± 0.12

0.78 ± 0.06

1.27 ± 0.37

0.78 ± 0.23

0.77 ± 0.09

0.45 ± 0.11

0.90 ± 0.14

 EOS (× 109/L)

0.19 ± 0.06

0.73 ± 0.18

0.32 ± 0.06

0.37 ± 0.05

0.45 ± 0.09

0.31 ± 0.08

0.46 ± 0.09

 BASO (× 109/L)

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

 RBC (× 1012/L)

7.85 ± 0.39

8.86 ± 0.26

8.39 ± 0.13

8.06 ± 0.19

8.49 ± 0.37

8.11 ± 0.22

8.49 ± 0.31

 Hb (g/dL)

13.95 ± 0.05

15.77 ± 0.49*

15.03 ± 0.19

14.67 ± 0.18

15.07 ± 0.64

14.67 ± 0.60

15.37 ± 0.52

 HCT (%)

41.65 ± 0.65

49.23 ± 1.13*

46.87 ± 0.99*

45.70 ± 0.64

48.87 ± 1.07

47.90 ± 1.74

47.23 ± 2.14

 MCV (fL)

53.25 ± 3.45

56.80 ± 1.24

55.87 ± 0.84

56.80 ± 1.20

57.67 ± 1.26

59.07 ± 1.32

55.57 ± 0.58

 MCH (pg)

17.80 ± 0.80

17.83 ± 0.15

17.93 ± 0.15

18.20 ± 0.25

17.77 ± 0.17

18.07 ± 0.47

18.10 ± 0.10

 MCHC (g/dL)

33.50 ± 0.60

31.37 ± 0.58

32.10 ± 0.32

32.10 ± 0.55

30.83 ± 0.65*

30.60 ± 0.17*

32.53 ± 0.37

 RDW-CV (%)

16.85 ± 2.05

18.60 ± 0.40

19.83 ± 0.32

19.30 ± 0.99

19.27 ± 0.53

17.97 ± 0.58

18.37 ± 0.93

 PLT(× 109/L)

706.0 ± 14.29

722.0 ± 23.18

808.3 ± 61.87

734.0 ± 26.63

799.7 ± 52.14

793.7 ± 45.95

855.3 ± 139.0

 MPV (fL)

7.35 ± 0.15

8.27 ± 0.09*

8.23 ± 0.09*

8.20 ± 0.20*

9.33 ± 0.19*

8.60 ± 0.40

8.23 ± 0.35

Males

 WBC (× 109/L)

12.54 ± 1.69

10.68 ± 2.24

12.08 ± 2.34

13.74 ± 0.46

8.99 ± 1.07

11.45 ± 2.82

13.56 ± 3.24

 NEU (× 109/L)

2.77 ± 0.56

3.69 ± 0.98

3.58 ± 1.56

2.32 ± 0.32

2.49 ± 0.61

2.94 ± 0.75

3.55 ± 0.43

 LYM(× 109/L)

8.61 ± 1.70

5.72 ± 1.09

7.20 ± 0.57

9.69 ± 0.28

5.38 ± 0.97

7.03 ± 1.85

8.65 ± 3.01

 MONO (× 109/L)

0.92 ± 0.29

0.71 ± 0.19

0.92 ± 0.23

0.91 ± 0.05

0.70 ± 0.15

0.89 ± 0.30

0.83 ± 0.29

 EOS (× 109/L)

0.35 ± 0.03

0.56 ± 0.04

0.38 ± 0.08

0.67 ± 0.05

0.42 ± 0.10

0.58 ± 0.29

0.53 ± 0.09

 BASO (× 109/L)

0.0033 ± 0.0033

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

 RBC (× 1012/L)

7.66 ± 0.88

7.94 ± 0.59

8.80 ± 0.26

9.64 ± 0.09

8.76 ± 0.33

9.32 ± 0.54

9.04 ± 0.29

 Hb (g/dL)

13.63 ± 1.47

13.40 ± 0.82

15.10 ± 0.44

16.23 ± 0.17

15.60 ± 0.49

15.83 ± 0.94

16.00 ± 0.46

 HCT (%)

40.67 ± 4.91

41.73 ± 2.44

45.43 ± 1.34

49.53 ± 1.09

49.07 ± 1.43

49.50 ± 2.91

49.43 ± 1.62

 MCV (fL)

53.03 ± 1.02

52.67 ± 0.90

51.60 ± 0.15

51.43 ± 1.28

56.07 ± 0.58

53.13 ± 1.59

54.67 ± 0.50

 MCH (pg)

17.83 ± 0.15

16.93 ± 0.22*

17.17 ± 0.03

16.87 ± 0.17*

17.80 ± 0.12

16.93 ± 0.23*

17.67 ± 0.07

 MCHC (g/dL)

33.63 ± 0.68

32.10 ± 0.26

33.27 ± 0.03

32.80 ± 0.50

31.77 ± 0.18

32.00 ± 0.52

32.40 ± 0.26

 RDW-CV (%)

20.80 ± 1.18

20.77 ± 0.57

20.60 ± 0.61

21.40 ± 0.72

19.30 ± 0.17

21.00 ± 0.91

21.50 ± 0.66

 PLT(× 109/L)

1014 ± 220.6

742.0 ± 49.14

723.7 ± 80.05

751.3 ± 47.64

687.7 ± 70.48

754.3 ± 31.44

759.3 ± 43.84

 MPV (fL)

7.03 ± 0.67

8.27 ± 0.18

7.97 ± 0.17

7.67 ± 0.09

8.67 ± 0.09

8.60 ± 0.40

8.20 ± 0.23

  1. Data are expressed as Mean ± SEM; **significant p-value when control is compared with male and female combined *significant p-value when control is compared with treatment groups (male and females separated). n (number of rats) = 6/group for treated groups while 5/group for control for the combined analysis. n = 3/group for the separate group analysis