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Table 3 Effect of Etpost (2 μg/ml) against the RISK/SAFE kinase inhibitors on arrhythmia score, VT, and VF incidence during the reperfusion phase of the IR model

From: Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart

 

Arrhythmia

score

VT incidence

(%)

VF incidence

(%)

IR (Con.)@

3.23 ± 0.85

69.23

30.77

IPOST (Con.)

2.30 ± 0.75*

50.00*

10.00*

Etpost (2 μg/ml)

4.33 ± 0.93*

100.0*

00.00*

Etpost (2 μg/ml) + Wort

6.50 ± 0.83*,#

100.0*

66.67*,#

Etpost (2 μg/ml) + PD

5.67 ± 0.34*,#

66.67#

100.0*,#

Etpost (2 μg/ml) + AG

6.25 ± 0.75*,#

50.0*,#

100.0*,#

Etpost (2 μg/ml) + HD

2.20 ± 0.17*,#

100.0*

00.000*

IPOST + Wort

7.00 ± 0.00*,&

100.0*,&

100.0*,&

IPOST + PD

7.00 ± 1.17*,&

100.0*,&

100.0*,&

IPOST + AG

5.75 ± 1.25*,&

50.00*

50.00*,&

IPOST + HD

3.00 ± 0.05&

33.33*,&

33.33&

  1. IR ischemic reperfusion, VT ventricular tachycardia, VF ventricular fibrillation, Etpost Ethyl acetate fraction of Potentilla reptans root in postconditioning, Wort Wortmanin (PI3K/Akt inhibitor), PD PD98059 (ERK inhibitor), AG AG490 a JAK/STAT3 inhibitor, HD 5HD a mitoKATP channel blocker. The scale range of arrhythmia score is 0–7. Data are presented as mean ± SEM. *P < 0.05 vs. IR; & P < 0.05 vs. IPOST; # P < 0.05 vs. Etpost (2 μg/ml). @: [7]