Table 2 Effect of Etpost (2 μg/ml) against the RISK/SAFE kinase inhibitors on functional hemodynamic parameters of the isolated rat heart during the reperfusion time

IR (Con.)^@

39.35 ± 15.9

35.42 ± 14.3

121.8 ± 20.4

39.75 ± 16.7

38.67 ± 15.7

34.49 ± 12.9

4.75 ± 0.25 [7]

IPOST (Con.)

79.93 ± 9.52^*

73.30 ± 6.70^*

91.62 ± 5.73^*

67.76 ± 13.5^*

72.91 ± 6.98^*

73.26 ± 6.51^*

7.56 ± 0.05^*

Etpost (2 μg/ml)

78.81 ± 3.22^*

67.24 ± 3.76^*

85.62 ± 4.57^*

77.69 ± 3.94^*

75.36 ± 3.61^*

65.85 ± 6.07^*

6.10 ± 0.06^*

Etpost (2 μg/ml) + Wort

66.09 ± 12.6^#’$

67.89 ± 11.2^$

101.38 ± 15.7^{#, $}

72.64 ± 13.6^$

69.62 ± 12.7^$

60.19 ± 7.16^$

3.28 ± 2.42^#

Etpost (2 μg/ml) + PD

72.85 ± 12.4^$

72.69 ± 13.3^$

98.58 ± 5.03^#

85.78 ± 8.93^{#, $}

82.92 ± 15.6^{#, $}

66.52 ± 12.7^$

10.3 ± 1.11^#

Etpost (2 μg/ml) + AG

56.37 ± 14.7^#

47.10 ± 19.4^#

70.26 ± 13.9^#

62.13 ± 15.1^{#, $}

52.53 ± 15.7^#

46.43 ± 16.9^#

3.05 ± 2.42^{#, $}

Etpost (2 μg/ml) + HD

74.07 ± 2.86^$

66.83 ± 2.91^$

90.73 ± 7.57

123.9 ± 5.91^{#, $}

76.13 ± 1.85^$

67.38 ± 1.67^$

2.84 ± 0.34^#

IPOST + Wort

51.73 ± 9.77^&

48.89 ± 9.34^&

73.54 ± 15.92^&

81.72 ± 11.5^&

57.70 ± 8.94^&

49.86 ± 7.95^&

3.83 ± 1.42^&

IPOST + PD

43.70 ± 9.97^&

42.06 ± 11.9^&

94.85 ± 16.5

40.64 ± 11.0^&

44.97 ± 7.73^&

37.76 ± 5.65^&

5.10 ± 0.77^&

IPOST + AG

49.39 ± 13.2^&

46.71 ± 12.2^&

78.87 ± 1.90^&

99.48 ± 26.6^&

54.59 ± 18.7^&

47.38 ± 19.9^&

0.75 ± 0.58^&

IPOST + HD

61.62 ± 8.18^&

57.83 ± 9.10^&

90.66 ± 5.43

65.33 ± 15.1

57.47 ± 13.1^&

56.95 ± 10.0^&

3.00 ± 1.14^&