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Table 4 Effects of M. pruriens extract on selected antioxidant enzymes (superoxide dismutase and Catalase) and reduced glutathione (GSH) in the liver and kidney of rats after CCl4 and rifampicin induced toxicity

From: Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Parameters

Tissues

Negative Control

Positive Control (CCl4 only)

CCl4 + 50 mg/kg b.w MP

CCl4 + 100 mg/kg b.w MP

CCl4 + 100 mg/kg b.w Silymarin

Negative Control II (Rifampicin only)

Rifampicin + 50 mg/kg b.w MP

Rifampicin + 100 mg/kg b.w MP

SOD (μmol/min/mg protein)

Liver

6.14 ± 0.31a

4.53 ± 0.22

4.72 ± 0.61a

4.93 ± 0.31a

6.20 ± 1.23a

2.36 ± 0.19

2.75 ± 0.12a

3.89 ± 0.15a

Kidney

3.48 ± 1.03a

2.46 ± 0.75

2.61 ± 0.54a

2.90 ± 0.44a

3.15 ± 0.53a

1.93 ± 0.19

2.76 ± 0.41a

3.08 ± 0.26a

Serum

4.29 ± 0.19a

3.17 ± 0.10

3.28 ± 0.18a

4.00 ± 0.33a

4.34 ± 0.21a

2.42 ± 0.07

2.89 ± 0.13a

3.76 ± 0.21a

Catalase (μmol/min/mg protein)

Liver

4.70 ± 0.56a

2.89 ± 0.21

3.15 ± 0.11a

4.15 ± 0.30a

3.97 ± 1.20a

1.63 ± 0.16

2.60 ± 0.41a

3.84 ± 0.23a

Kidney

2.77 ± 0.15a

2.02 ± 0.18

2.32 ± 0.20a

2.47 ± 0.11a

2.58 ± 0.20a

1.88 ± 0.26

2.16 ± 0.12a

2.53 ± 0.10a

Serum

3.06 ± 0.11a

2.38 ± 0.10

2.66 ± 0.14a

2.91 ± 0.10a

2.93 ± 0.20a

1.76 ± 0.14

2.53 ± 0.20a

3.01 ± 0.16a

GSH ((μmol/mg protein)

Liver

5.77 ± 0.06a

3.87 ± 0.01

4.20 ± 0.12a

5.13 ± 0.10a

5.43 ± 0.08a

2.93 ± 0.08

3.17 ± 0.02a

4.22 ± 0.06a

Kidney

3.23 ± 0.07a

2.53 ± 0.05

2.88 ± 0.08a

3.07 ± 0.09a

3.19 ± 0.12a

3.04 ± 0.02

3.15 ± 0.08a

3.19 ± 0.10a

Serum

2.66 ± 0.10a

1.57 ± 0.22

2.07 ± 0.64a

2.10 ± 0.52a

2.49 ± 0.98a

2.08 ± 0.02

2.30 ± 0.04a

2.52 ± 0.01a

  1. Data shows mean ± SEM values of four independent experiments performed in triplicate ‘a’ represents significant difference (p < 0.05) from the control, (n = 5)