Fig. 1
Representative photomicrograph of the liver (A-D) and kidney (E-G) slices of experimental animals. A-D, showing a high-power magnification (× 400 mag) of the inherent hepatocytes (black arrow head). Photomicrographs show the histomorphological manifestation of the hepatocytes, density of hepatocytes, distribution of hepatocytes, staining intensity of hepatocytes, size of central veins, content of central veins and expression of large vacuolations (dotted black circles). Large vacoulations with pick colouration are fatty livers with bile plaques which suggests cholestasis. Similarly, E-G showing a high-power magnification (x400mag) of renal corpuscle (black outline) which houses the glomerulus within the urinary space that is supplied by the afferent arteriole and drained by the efferent arteriole. The histomorphology presents with the convoluted tubule (CT), glomerular capillaries (GC) and inherent cells which include the intraglomerular podocytes (P) as well as the juxtaglomerular cells and macula densa cells in the vascular poles of the renal corpuscles. The urinary pole continues out as the proximal convoluted tubules. A- liver slice of animals fed with animal feed and distilled water only; B- liver slice of animals administered with 3 ml/kg CCl4, without treatment; C- liver slice of animals induced with 3 ml/kg CCl4 and treated with 100 mg/kg M. pruriens; D - liver slice of animals administered with 3 ml/kg CCl4 and treated with 200 mg/kg Silymarin; E - kidney slice of animals administered with distilled water only; F - kidney slice of animals administered with 250 mg/kg rifampicin only without treatment; G- kidney slice of animals administered with 250 mg/kg rifampicin and treated with 100 mg/kg bw of M. pruriens