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Table 4 Effects of polyphenol rich extract of Ocimum gratissimum leaves on some parameter of renal function in cyclophosphamide-treated rats

From: Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

Creatinine Concentration

Plasma Level

Urine Level

Groups

(μmol/L)

(μmol/L)

 [1] Control

34.48 ± 4.33

1768.4 ± 5.56

 [2] PREOG (400 mg/kg)

39.79 ± 2.38

1945.24 ± 8.65

 [3] CP (50 mg/kg)

168.00 ± 3.23*

970.85 ± 4.33*

 [4] PREOG (400 mg/kg) + CP

44.21 ± 4.57#

1670.25 ± 6.45#

Urea Concentration

Plasma Level

Urine Level

Groups

(mmol/L)

(mmol/L)

 [1] Control

5.90 ± 0.27

200.02 ± 21.39

 [2] PREOG (400 mg/kg)

7.00 ± 0.92

200.90 ± 15.88

 [3] CP (50 mg/kg)

16.70 ± 5.26*

130.03 ± 20.19*

 [4] PREOG (400 mg/kg) + CP

11.95 ± 0.42*#

179.67 ± 30.38#

Cystatin C Concentration

Plasma Level

Urine Level

Groups

(ng/ml)

(ng/ml)

 [1] Control

0.23 ± 0.31

12.34 ± 3.01

 [2] PREOG (400 mg/kg)

0.25 ± 0.44

13.30 ± 2.08

 [3] CP (50 mg/kg)

0.59 ± 0.66*

25.34 ± 1.19*

 [4] PREOG (400 mg/kg) + CP

0.43 ± 0.23#

15.08 ± 1.38#

Albumin

Plasma Level

Urine Level

Groups

(g/dl)

(mg/dl)

 [1] Control

6.44 ± 0.55

0.19 ± 0.71

 [2] PREOG (400 mg/kg)

7.09 ± 0.21

0.22 ± 1.01

 [3] CP (50 mg/kg)

3.22 ± 0.25*

1.25 ± 0.91*

 [4] PREOG (400 mg/kg) + CP

5.78 ± 1.01#

0.28 ± 0.08#

Albumin/Creatinine Ratio

(mg/g)

 

Groups

  

 [1] Control

9.91 ± 0.51

 

 [2] PREOG (400 mg/kg)

10.70 ± 1.32

 

 [3] CP (50 mg/kg)

113.8 ± 4.66*

 

 [4] PREOG (400 mg/kg) + CP

14.80 ± 0.52#

 
  1. Each value represents mean ± SEM (n = 7). * (p < 0.05) = significantly different from control in the same column. # (p < 0.05) = significantly different from CP (50 mg/kg) in the same column