Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

Table 3 Effects of polyphenol rich extract of Ocimum gratissimum leaves on water intake, urine output, food consumption (g) and body weight (g) in cyclophosphamide-treated rats

	Baseline	24 h. after 7 days of administration of drugs
Water Intake (ml/24 h)
[1] Control	17.70 ± 0.40	18.70 ± 0.59
[2] PREOG 400 mg/kg	15.70 ± 0.73	19.60 ± 0.43
[3] CP (50 mg/kg)	18.30 ± 1.69	30.80 ± 1.33*
[4] PREOG 400 mg/kg + CP	15.90 ± 1.76	20.10 ± 1.66^#
Urine Output (ml/24 h.)
[1] Control	12.60 ± 0.21	13.10 ± 0.19
[2] PREOG (400 mg/kg)	13.10 ± 0.35	14.60 ± 0.33
[3] CP (50 mg/kg)	14.00 ± 1.39	20.85 ± 1.03*
[4] PREOG (400 mg/kg) + CP	14.11 ± 1.44	16.00 ± 1.46^#
Food consumption (g)
[1] Control	11.60 ± 0.80	15.80 ± 0.13
[2] PREOG (400 mg/kg)	14.80 ± 0.43	20.60 ± 0.33
[3] CP (50 mg/kg)	12.80 ± 1.29	10.06 ± 1.03*
[4] PREOG (400 mg/kg) + CP	12.20 ± 1.42	14.50 ± 1.06^#
Body weight (g)
[1] Control	135.40 ± 3.37	150.00 ± 2.44
[2] PREOG (400 mg/kg)	150.00 ± 1.75	170.20 ± 4.00
[3] CP (50 mg/kg)	145.20 ± 4.89	129.10 ± 2.01*
[4] PREOG (400 mg/kg) + CP	150.60 ± 6.47	146.40 ± 3.16^#

Each value represents mean ± SEM (n = 7). * (p < 0.05) = significantly different from control in the same column. ^# (p < 0.05) = significantly different from CP (50 mg/kg) in the same column

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