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Table 1 Nephrotoxicity scoring system in histopathology

From: Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

Grade

Glomerular Damage

Tubular damage

Tubulointerstitial inflammatory infiltrates

0

None (Normal)

None (Normal)

None (Normal)

1

<  25% of Glomeruli

< 25% of parenchymal tubules

Leucocytes only in interstitium

2

25–50% of Glomeruli

25–50% of parenchymal tubules

Leucocytes in both interstitium and tubular epithelial cells

3

50–75% of Glomeruli

50–75% of parenchymal tubules

_

4

>  75% of Glomeruli

> 75% of parenchymal tubules

_

  1. Total score of 0–2 represents none/mild nephrotoxicity, 3–6 moderate nephrotoxicity, 7–10 severe nephrotoxicity