Fig. 5

The histoarchitecture of the control, and PREOG groups show normal renal parenchymal tissue with intact glomeruli, proximal and distal convoluted tubules and loop of Henle. The blood vessels are intact. Histoarchitecture of CP shows renal tissue with marked alteration of the renal parenchymal tissue owing to severe destruction/damage of the glomeruli (black arrow), proximal and distal convoluted tubules (blue arrows). Infiltration of the interstitium by chronic inflammatory cells mostly neutrophils were also seen in CP treated rats (brown arrow). However, PREOG + CP group renal architecture show mild alteration in glomeruli and mild infiltration of the interstitium with inflammatory cells. The proximal and distal convoluted tubules and loop of Henle were intact in this group than CP alone group (PAS, X400)