Table 1 MIC and MFC values obtained for Candida spp. reference strains and clinical isolates incubated with commercial fungicides (fluconazole, ketoconazole, itraconazole, nystatin and amphotericin B). Candida spp. strains and isolates were incubated with different concentrations of the fungicides, as suggested by the M27-A3 protocol from the CLSI (2008). MIC - Minimal Inhibitory Concentration; MFC - Minimal Fungicidal Concentration; (S) - Susceptible; (S-DD) - Dose-dependent Susceptibility; (R) - Resistant

2508

C. albicans

0.125 (S)

0.125

0.03125

0.03125

0.03125 (S)

0.03125

4

4

1

1

2517

C. albicans

0.25 (S)

0.25

0.03125

0.03125

0.125 (S)

0.0125

4

8

1

1

3703

C. albicans

0.125 (S)

0.125

0.03125

0.03125

0.03125 (S)

0.03125

4

4

0.5

0.5

3704

C. albicans

0.5 (S)

0.5

0.03125

0.0625

0.03125 (S)

0.03125

2

4

0.5

0.5

PAC 01

C. dubliniensis

32 (S-DD)

> 64

0.03125

0.125

8 (R)

> 16

2

4

2

2

PAC 02

C. tropicalis

2 (S)

16

0.03125

0.125

0.25 (S-DD)

0.5

2

4

2

2

PAC 04

C. tropicalis

0.125 (S)

0.5

0.03125

0.03125

0.03125 (S)

0.03125

0.5

2

0.25

0.5

PAC 05

C. tropicalis

8 (R)

> 64

0.25

> 16

1 (R)

> 16

2

4

2

4

PAC 06

C. albicans

0.25 (S)

2

0.0625

0.125

0.0625 (S)

0.5

4

4

2

2

PAC 08

C. albicans

1 (S)

8

0.03125

0.125

0.25 (S-DD)

2

2

4

2

2

PAC 13

C. albicans

0.5 (S)

16

0.03125

> 16

0.0625 (S)

0.25

1

4

0.5

2

PAC 15

C. tropicalis

2 (S)

> 64

0.03125

> 16

2 (R)

8

1

4

2

2

PAC 17

C. albicans

16 (R)

> 64

0.03125

> 16

2 (R)

> 16

16

> 16

4

4

PAC 18

C. albicans

1 (S)

> 64

0.03125

> 16

0.25 (S-DD)

> 16

16

16

1

2

PAC 19

C. albicans

4 (S-DD)

16

0.125

1

1 (R)

8

8

8

0.5

0.5

PAC 20

C. albicans

4 (S-DD)

> 64

0.0625

> 16

1 (R)

> 16

4

16

0.25

0.5