Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches

Table 1 α-Glucosidase and α-amylase inhibitory potentials of Notholirion thomsonianum

Samples	Conc (μg/mL)	Alpha glucosidase		Alpha amylase
Samples	Conc (μg/mL)	Percent Inhibition (mean ± SEM)	IC₅₀ (μg/mL)	Percent Inhibition (mean ± SEM)	IC₅₀ (μg/mL)
Nt.Cr	1000 500 250 125 62.5	64.78 ± 0.92* 54.11 ± 0.07* 51.55 ± 0.41* 47.55 ± 0.67* 40.00 ± 0.57***	185	62.41 ± 0.24 57.65 ± 0.01* 54.62 ± 0.63 45.32 ± 0.41* 41.10 ± 0.48***	180
Nt.Hex	1000 500 250 125 62.5	57.44 ± 0.60* 51.45 ± 0.57* 44.84 ± 0.39* 39.13 ± 0.92* 32.00 ± 1.00***	435	60.52 ± 0.52 57.52 ± 0.52* 50.24 ± 0.27 46.52 ± 0.51* 38.22 ± 0.82***	240
Nt.Chf	1000 500 250 125 62.5	59.69 ± 1.21* 53.88 ± 1.04* 47.28 ± 1.15* 42.31 ± 0.48* 35.00 ± 0.00***	394	56.53 ± 1.01* 51.23 ± 0.86* 43.52 ± 1.03* 39.12 ± 0.93* 36.53 ± 0.52***	450
Nt.EtAc	1000 500 250 125 62.5	68.57 ± 1.26* 61.89 ± 1.70* 57.77 ± 1.01* 53.61 ± 2.31* 45.33 ± 0.66***	67	71.30 ± 0.83^ns 64.42 ± 1.20 ^ns 60.52 ± 1.54^ns 55.63 ± 1.65^ns 48.35 ± 1.08 ^ns	70
Nt.Aq	1000 500 250 125 62.5	55.77 ± 0.95* 48.55 ± 1.75* 39.35 ± 0.21* 33.75 ± 0.44* 28.00 ± 0.00***	614	47.53 ± 0.24* 43.74 ± 1.32* 37.52 ± 1.54* 29.32 ± 0.63* 26.53 ± 0.27***	950
Acarbose	1000 500 250 125 62.5	76.87 ± 0.06 73.94 ± 1.92 67.49 ± 0.22 61.53 ± 0.89 55.50 ± 1.00	6.84	78.63 ± 0.54 71.65 ± 0.71 68.95 ± 1.20 64.52 ± 0.21 57.63 ± 0.59	13

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