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Fig. 7 | BMC Complementary Medicine and Therapies

Fig. 7

From: Combined antihypertensive effect of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. Extracts in 1 kidney-1 clip hypertensive rats and spontaneously hypertensive rats

Fig. 7

HDR-2 reduces blood pressure in spontaneously hypertensive rats (SHRs). Effects of long-term oral administration of HDR-2 on (a) systolic blood pressure (SBP, mmHg), (b) variation in blood pressure (ΔSBP, mmHg) and (c) heart rate (HR, bpm) as measured by tail-cuff plethysmography in SHRs. SHRs in the low-dose (150 mg/kg BW) and high-dose (300 mg/kg BW) groups were orally administered HDR-2 every day over a period of 5 weeks. SHRs in the combined L-arginine and GABA group (SHR/Arg + GABA) were given a mixture at 10 mg/kg BW once daily, whereas the SHRs and WKYs in the control groups were given saline (0.5 mL). Values are expressed as the mean ± SD. ** and *** indicate P < 0.01 and P < 0.001, respectively, compared with the WKY control group (WKY); ## and ### indicate P < 0.01 and P < 0.001, respectively, compared with the SHR control group. NS indicates not significant

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