Fig. 4

Effect of HDR-2 on systolic blood pressure (SBP) in 1 K-1C hypertensive rats at 0–2 weeks. Rats were intragastrically treated with saline, HDR-2, or a mixture of _L-arginine and GABA, and SBP was measured using a NIBP system at 0, 1 and 2 weeks prior. Normal control (NCTL, 2 K-NC), sham-operated control (1 K-NC) and 1 K-1C control: rats were treated with saline. 1 K-1C/HDR-2: 1 K-1C rats were treated with HDR-2150 mg/kg BW or 300 mg/kg BW. 1 K-1C/Arg + GABA: 1 K-1C rats were treated with _L-arginine (4 mg/kg BW) and GABA (6 mg/kg BW). Seven rats (n = 7) were included in each group. Values are expressed as the mean ± SD. *, ** and *** indicate P < 0.05, P < 0.01 and P < 0.001, respectively, compared with the sham-operated control (1 K-NC), #, ## and ### indicate P < 0.05, P < 0.01 and P < 0.001, respectively, compared with the 1 K-1C control group