Fig. 6

DISS rescued cognitive deficits in APP/PS1 mice. After 4-weeks treatment, MWM test was carried out to examine the cognitive function of mice in each group. (A) The representative swimming paths of each group in the training trails at day 5; (B) The escape latency in the training trials; (C) The swimming distances before crossing the platform; (D) The time spent in the target quadrant; (E) The times of platform crossing; (F) The swimming velocity in the probe trails. #P < 0.05; ##P < 0.01 vs. WT group; *P < 0.05; **P < 0.01 vs. APP/PS1 group. Data are represented as mean ± sem. n = 10 mice in each group. The escape latencies in different groups were analyzed by repeated-measures two-way ANOVA, and the other data were analyzed by one-way ANOVA