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Table 1 List of deregulated proteins in LPS-stimulated synovial cells

From: The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells

Accession

Group Profile (Ratio)

Gene names (primary)

Description

OA associated

human OA DEG

induced OA DEG

OA gene interaction

skeletal phenotype

Proteins down-regulated by LPS

 Q92598

0.23

HSPH1

Heat shock protein 105 kDa

false

2

8

14

false

 P49327

0.25

FASN

Fatty acid synthase

false

3

7

17

false

   Q9Y3C0

0.26

WASHC3

WASH complex subunit 3

false

1

1

3

false

 Q9H4B7

0.32

TUBB1

Tubulin beta-1 chain

false

5

1

3

false

 P45877

0.36

PPIC

Peptidyl-prolyl cis-trans isomerase C

false

8

9

0

false

 Q12768

0.43

WASHC5

WASH complex subunit 5

false

0

0

2

false

 P07996

0.45

THBS1

Thrombpondin-1

true

4

2

19

true

 Q8WWI1

0.45

LMO7

LIM domain only protein 7

false

3

5

7

false

 Q8WX93

0.47

PALLD

Palladin

false

3

2

5

false

 Q8NHP8

0.48

PLBD2

Putative phpholipase B-like 2

false

0

0

2

false

 Q8NE86

0.49

MCU

Calcium uniporter protein mitochondrial

false

0

0

0

false

 O60831

0.51

PRAF2

PRA1 family protein 2

false

1

3

0

false

 Q9UMX0

0.52

UBQLN1

Ubiquilin-1

false

1

1

15

false

 Q9NR12

0.52

PDLIM7

PDZ and LIM domain protein 7

false

5

3

7

false

 O00154

0.52

ACOT7

Cytolic acyl coenzyme A thioester hydrolase

false

0

3

1

false

 Q9Y305

0.53

ACOT9

Acyl-coenzyme A thioesterase 9 mitochondrial

false

0

4

6

false

 Q71U36

0.53

TUBA1A

Tubulin alpha-1A chain

false

1

1

31

false

 P15374

0.53

UCHL3

Ubiquitin carboxyl-terminal hydrolase isozyme L3

false

0

7

5

false

 Q04760

0.53

GLO1

Lactoylglutathione lyase

false

0

3

3

true

 P30419

0.53

NMT1

Glycylpeptide N-tetradecanoyltransferase 1

false

1

1

4

false

 P55809

0.54

OXCT1

Succinyl-CoA:3-ketoacid coenzyme A transferase 1 mitochondrial

false

2

4

3

false

 O43504

0.55

LAMTOR5

Ragulator complex protein LAMTOR5

false

0

1

4

false

 P62841

0.55

RPS15

40S ribomal protein S15

false

1

5

9

false

 P36776

0.55

LONP1

Lon protease homolog mitochondrial

false

4

3

7

false

 Q12849

0.55

GRSF1

G-rich sequence factor 1

false

0

1

2

false

 Q5JRX3

0.55

PITRM1

Presequence protease mitochondrial

false

2

3

2

false

 Q8TDQ7

0.55

GNPDA2

Glucamine-6-phphate isomerase 2

false

0

1

1

false

 P34932

0.56

HSPA4

Heat shock 70 kDa protein 4

false

0

2

39

false

 Q15691

0.56

MAPRE1

Microtubule-associated protein RP/EB family member 1

false

0

0

13

false

 P24539

0.56

ATP5PB

ATP synthase F(0) complex subunit B1 mitochondrial

false

0

0

6

false

 P00491

0.56

PNP

Purine nucleide phphorylase

false

6

3

1

false

 P69905

0.56

HBA1; HBA2

Hemoglobin subunit alpha

false

7

0

3

false

 Q15008

0.57

PSMD6

26S proteasome non-ATPase regulatory subunit 6

false

0

5

4

false

 P02768

0.57

ALB

Albumin

false

2

0

9

false

 Q9UHB6

0.57

LIMA1

LIM domain and actin-binding protein 1

false

2

4

9

true

 Q15843

0.57

NEDD8

NEDD8

false

0

3

9

false

 P15848

0.58

ARSB

Arylsulfatase B

false

3

6

1

true

 O95202

0.58

LETM1

Mitochondrial proton/calcium exchanger protein

false

0

2

3

false

 P12109

0.59

COL6A1

Collagen alpha-1(VI) chain

true

6

12

9

false

 Q9UNZ2

0.59

NSFL1C

NSFL1 cofactor p47

false

0

1

8

false

 Q9Y5L4

0.59

TIMM13

Mitochondrial import inner membrane translocase subunit Tim13

false

0

3

3

false

 P55795

0.61

HNRNPH2

Heterogeneous nuclear ribonucleoprotein H2

false

0

2

5

true

 Q9H008

0.61

LHPP

Phpholysine phphohistidine inorganic pyrophphate phphatase

false

4

5

0

false

 P12111

0.62

COL6A3

Collagen alpha-3(VI) chain

false

6

16

2

true

 O14745

0.62

SLC9A3R1

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

false

1

4

11

true

 P98179

0.62

RBM3

RNA-binding protein 3

false

1

1

5

false

 Q14318

0.62

FKBP8

Peptidyl-prolyl cis-trans isomerase FKBP8

false

1

2

10

true

 O94826

0.62

TOMM70

Mitochondrial import receptor subunit TOM70

false

0

2

4

false

 P48509

0.62

CD151

CD151 antigen

false

0

1

0

false

 O75348

0.62

ATP6V1G1

V-type proton ATPase subunit G 1

false

1

2

0

false

 P60953

0.63

CDC42

Cell division control protein 42 homolog

true

0

0

19

true

 Q9BRA2

0.63

TXNDC17

Thioredoxin domain-containing protein 17

false

1

1

0

false

 Q9BRF8

0.63

CPPED1

Serine/threonine-protein phphatase CPPED1

false

2

0

0

false

 Q07666

0.64

KHDRBS1

KH domain-containing RNA-binding signal transduction-associated protein 1

false

0

2

16

true

 Q16795

0.64

NDUFA9

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 mitochondrial

false

0

2

6

false

 O75431

0.64

MTX2

Metaxin-2

false

0

1

0

false

 Q9C0H2

0.64

TTYH3

Protein tweety homolog 3

false

1

4

0

false

 Q5JPE7

0.64

NOMO2

Nodal modulator 2

false

0

0

1

false

 P69849

0.64

NOMO3

Nodal modulator 3

false

0

0

1

false

 P00966

0.65

ASS1

Argininuccinate synthase

false

4

2

4

false

 O75531

0.65

BANF1

Barrier-to-autointegration factor

false

0

2

2

false

 O95372

0.65

LYPLA2

Acyl-protein thioesterase 2

false

0

0

1

false

 Q9P1F3

0.65

ABRACL

Ctars family protein ABRACL

false

3

2

0

false

 Q15233

0.66

NONO

Non-POU domain-containing octamer-binding protein

false

0

2

16

false

 P14324

0.66

FDPS

Farnesyl pyrophphate synthase

false

0

2

3

false

 P60983

0.66

GMFB

Glia maturation factor beta

false

1

2

1

false

Protein up-regulated by LPS

 Q96AT9

51.49

RPE

Ribulose-phosphate 3-epimerase

false

0

0

3

false

 O14684

4.09

PTGES

Prostaglandin E synthase

false

8

4

0

false

 P43490

3.35

NAMPT

Nicotinamide phphoribyltransferase

true

8

0

4

false

 O43776

2.66

NARS1

Asparagine--tRNA ligase cytoplasmic

false

0

0

3

false

 Q5VYK3

2.56

ECPAS

Proteasome adapter and scaffold protein ECM29

false

1

0

8

false

 P12955

2.47

PEPD

Xaa-Pro dipeptidase

false

0

5

5

true

 P10301

2.33

RRAS

Ras-related protein R-Ras

false

3

1

5

false

 P19827

2.27

ITIH1

Inter-alpha-trypsin inhibitor heavy chain H1

false

0

1

1

false

 P15121

2.04

AKR1B1

Aldo-keto reductase family 1 member B1

false

0

4

3

false

 O14828

1.96

SCAMP3

Secretory carrier-associated membrane protein 3

false

1

1

4

false

 P07711

1.95

CTSL

Cathepsin L1

false

4

0

3

false

 Q6IBS0

1.92

TWF2

Twinfilin-2

false

0

5

0

false

 P04179

1.9

SOD2

Superoxide dismutase [Mn] mitochondrial

true

7

7

8

false

 P54709

1.85

ATP1B3

Sodium/potassium-transporting ATPase subunit beta-3

false

1

3

3

false

 Q9Y3Z3

1.84

SAMHD1

Deoxynucleide triphphate triphphohydrolase SAMHD1

false

1

2

3

false

 Q9Y3A6

1.84

TMED5

Transmembrane emp24 domain-containing protein 5

false

3

3

0

false

 Q13501

1.79

SQSTM1

Sequestome-1

false

3

1

42

true

 Q96JJ7

1.79

TMX3

Protein disulfide-isomerase TMX3

false

0

0

0

false

 O75828

1.78

CBR3

Carbonyl reductase [NADPH] 3

false

2

5

3

false

 P35613

1.78

BSG

Basigin

false

2

0

7

false

 P26599

1.76

PTBP1

Polypyrimidine tract-binding protein 1

false

2

0

11

false

 Q9Y295

1.76

DRG1

Developmentally-regulated GTP-binding protein 1

false

0

1

2

false

 Q7L523

1.74

RRAGA

Ras-related GTP-binding protein A

false

0

3

2

false

 P61009

1.7

SPCS3

Signal peptidase complex subunit 3

false

2

1

1

false

 Q96HE7

1.69

ERO1A

ERO1-like protein alpha

false

5

1

1

false

 Q9UL46

1.66

PSME2

Proteasome activator complex subunit 2

false

0

0

2

false

 Q13724

1.63

MOGS

Mannyl-oligaccharide glucidase

false

0

2

5

false

 Q9Y5P6

1.63

GMPPB

Manne-1-phphate guanyltransferase beta

false

2

2

1

false

 P19525

1.61

EIF2AK2

Interferon-induced double-stranded RNA-activated protein kinase

false

1

1

18

false

 P02794

1.59

FTH1

Ferritin heavy chain

false

3

1

5

false

 P18085

1.58

ARF4

ADP-ribylation factor 4

false

2

10

10

false

 P23381

1.57

WARS1

Tryptophan--tRNA ligase cytoplasmic

false

0

0

3

false

 P63244

1.56

RACK1

Receptor of activated protein C kinase 1

false

1

0

22

false

 Q9NZ08

1.56

ERAP1

Endoplasmic reticulum aminopeptidase 1

false

1

1

3

false

 O95747

1.55

OXSR1

Serine/threonine-protein kinase R1

false

1

1

6

false

 P17858

1.54

PFKL

ATP-dependent 6-phphofructokinase liver type

false

1

3

6

false

 P08195

1.53

SLC3A2

4F2 cell-surface antigen heavy chain

false

6

0

7

false

 Q9UNN8

1.53

PROCR

Endothelial protein C receptor

false

4

8

0

false

 P04439

1.51

HLA-A

HLA class I histocompatibility antigen A alpha chain

false

1

0

5

false

 P50991

1.5

CCT4

T-complex protein 1 subunit delta

false

0

3

11

false