Skip to main content
Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells

Fig. 6

The combination of curcumin with bromelain and harpagophytum significantly reduced the LPS-induced expression of genes associated with inflammation and pain. Human synovial cells were treated with LPS (1 μg/ml) for 24 h in the presence of curcumin (CUR, 13 μM), bromelain (BRO, 14.7 μg/ml) and harpagophytum (HAR, 36 μg/ml), and all three together. At the end of the experiments, RNA were extracted and the media collected. Relative mRNA expression of NGF and IL-6 were determined by RT-PCR. Culture media were also collected and ELISA performed to assayed IL-6 and PGE2 release in medium. Values were compared to LPS-treated cells and presented as relative release (compared to the LPS group). n = 3. *: p-value< 0.05, **: p-value< 0.01, ***: p-value< 0.001

Back to article page