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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells

Fig. 5

The combination of curcumin with bromelain and harpagophytum significantly reduced the LPS-induced expression of genes associated with catabolism. Human synovial cells were treated with LPS (1 μg/ml) for 24 h in the presence of curcumin (CUR, 13 μM), bromelain (BRO, 14.7 μg/ml) and harpagophytum (HAR, 36 μg/ml), and all three together. A - At the end of the experiments, RNA was extracted and media collected. Relative mRNA expression of MMP-1, MMP-3 and MMP-13 was determined by RT-PCR. B - Culture media were also collected and ELISA performed to assayed MMP release in medium. Values were compared to LPS-treated cells and presented as relative expression (compared to the LPS group). n = 3. *: p-value< 0.05, **: p-value< 0.01, ***: p-value< 0.001

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