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Table 2 Quantification of the numbers of cognition-related neurons in mice

From: Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

 

B6

3xTg-AD

icv-saline

icv-saline

icv-STZ

Saline

PS128

Saline

PS128

Saline

PS128

NeuN

1299.8 ± 119.4

1576.6 ± 98.1

1356.5 ± 157.2

1266.3 ± 81.3

784.3 ± 109.7**

1305.2 ± 64.0##

ChAT

830.3 ± 68.7

944.7 ± 24.1

547.5 ± 13.3†††

491.0 ± 15.3

234.0 ± 36.5***

390.7 ± 60.4#

5-HT

136.0 ± 17.2

107.5 ± 7.8

63.3 ± 29.2

125.3 ± 7.1

46.0 ± 1.6***

118.3 ± 27.8##

TH

324.9 ± 22.3

271.0 ± 31.8

289.8 ± 33.2

266.5 ± 22.5

162.8 ± 9.2**

296.7 ± 25.5###

  1. Compared to B6 mice in the icv-saline/saline group
  2. *Compared to 3xTg-AD mice in the icv-saline/saline group
  3. #Compared to 3xTg-AD mice in the icv-STZ/saline group
  4. †††P < 0.001
  5. **P < 0.01; ***P < 0.001
  6. #P < 0.05; ##P < 0.01; ###P < 0.001