Fig. 8From: Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosisThe proposed effect of PS128 supplementation on 3 × Tg-AD mice treated with icv-STZ. The icv-STZ treatment substantially increased gliosis by increasing GSK3β activity and fecal PPA levels, resulting in cognitive dysfunction in 3 × Tg-AD mice. However, PS128 supplementation prevented the damage induced by icv-STZ, possibly by reducing PPA levels, GSK3β activity, and gliosis in 3 × Tg-AD mice, which further ameliorated the behavioral and pathological features of ADBack to article page