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Fig. 8 | BMC Complementary Medicine and Therapies

Fig. 8

From: Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Fig. 8

The proposed effect of PS128 supplementation on 3 × Tg-AD mice treated with icv-STZ. The icv-STZ treatment substantially increased gliosis by increasing GSK3β activity and fecal PPA levels, resulting in cognitive dysfunction in 3 × Tg-AD mice. However, PS128 supplementation prevented the damage induced by icv-STZ, possibly by reducing PPA levels, GSK3β activity, and gliosis in 3 × Tg-AD mice, which further ameliorated the behavioral and pathological features of AD

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