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Fig. 7 | BMC Complementary Medicine and Therapies

Fig. 7

From: Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Fig. 7

The effects of PS128 supplementation on cognition-related neurons in 3 × Tg-AD mice treated with icv-STZ. Representative images of immunostaining of mature pyramidal neurons with NeuN antibodies in the CA1 subregion of the hippocampus (a-f), cholinergic neurons with ChAT antibodies in the MS/DB (g-l), serotonergic neurons in the raphe nucleus (m-r), and noradrenergic neurons in the LC region (s-x) of different groups. Scale bars = 200 μm for NeuN, 5-HT, and TH and 500 μm for ChAT. Arrowheads, positive staining signals. Mature neuron (NeuN), serotonergic neuron (5-HT), noradrenergic neuron (TH), cholinergic neuron (ChAT), medial septum/diagnoid band (MS/DB), and locus coeruleus (LC)

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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