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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/β-catenin pathway

Fig. 4

Silencing H19 expression inhibited BMSC proliferation; alkaline phosphatase activity; BMP-2, RUNX2, and osteocalcin mRNA expression; and calcium nodule formation in quercetin-treated BMSCs. A H19 expression was inhibited after si-H19 transfection at 24 h and 21 days. B Transfected BMSC proliferation decreased on days 1, 2, and 7 after quercetin treatment. C Alkaline phosphatase (ALP) activity reduced after si-H19 transfection and quercetin treatment for 21 days; D BMP-2, RUNX2, and osteocalcin mRNA expression decreased after si-H19 transfection and quercetin treatment for 21 days. E Calcium nodule formation was reduced after si-H19 transfection and quercetin treatment for 21 days (400×). *P < 0.05 and ***P < 0.001 vs si-NC group

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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