Table 2 Characteristics of included trials on Huaiqihuang for Henoch-Schönlein purpura nephritis
Study ID | Sample size (E/C) | Age(years) (E/C) | Sex (Male) (E/C) | Clinical and pathological characteristics of samples | Intervention (on basis of BT) | Dosage and frequency of HQH | Duration of treatment | Follow-up | Outcomes | |
|---|---|---|---|---|---|---|---|---|---|---|
E | C | |||||||||
Duan CR 2017 [13] | 36/36 | 6.34 ± 2.55/6.38 ± 2.54 | 23/22 | Isolated hematuria/proteinuria; hematuria with proteinuria. | GC + HQH | GC | 10 g/time, Bid. | 4 weeks | 12 weeks | ①②⑩ |
Han DX 2014 [14] | 38/35 | Total 7.3 ± 2.4 | Total 42 | NR | GC + IS+HQH | GC + IS | ≤3 years old, 5 g/time, Bid; >3 years old, 10 g/time, Bid. | 8 weeks | NR | ①②③④⑩ |
Lu W 2015 [15] | 20/20 | 8.71 ± 5.02/8.12 ± 4.35 | 12/9 | NR | GC + HQH | GC | ≤5 years old, 5 g/time, Bid; >5 years old, 10 g/time, Bid. | 1 month | NR | ①②⑦⑧⑩ |
Peng YH 2014 [16] | 28/26 | 7.15 ± 4.79/7.10 ± 5.12 | 16/15 | Isolated hematuria/proteinuria; hematuria with proteinuria. | GC + HQH | GC | ≤3 years old, 5 g/time, Bid; >3 years old, 10 g/time, Bid.. | 3 months | NR | ①②⑧ |
Shi Z 2019 [17] | 15/15 | 8.89 ± 1.67/8.45 ± 1.74 | 9/8 | NR | GC + IS+HQH | GC + IS | 10 g/time, Bid. | 3 months | NR | ①②③④⑤⑦⑩ |
Yuan TT 2020 [18] | 47/47 | 8.6 ± 2.5/ 8.5 ± 2.6 | 31/33 | Isolated hematuria/proteinuria; hematuria with proteinuria; III-IV pathological grades. | GC + IS+HQH | GC + IS | 2–3 years old, 5 g/time, Bid; > 3 years old, 10 g/time, Bid. | 3 months | NR | ①②③④⑤⑧ |
Zhou DJ a 2013 [19] | 10/10 | Childen under 14 years | NR | II pathological grade. | HQH | BT alone | 10 g/time, Bid. | 2 months | NR | ③④⑥⑨ |
Zhou DJ b 2013 [19] | 5/5 | Childen under 14 years | NR | IIIa pathological grade. | GC + HQH | GC | 10 g/time, Bid. | 2 months | NR | ③④⑥⑨ |