Fig. 8

The production of IL-1β and TNF-α in human rheumatoid arthritis fibroblast-like synovial cells (RA-FLS). ELISA was used to quantify the IL-1β and TNF-α secretion. Myrtenal and β-caryophyllene oxide could significantly reduce IL-1β production. The production of TNF-α was also significantly decreased after treatment with myrtenal and β-caryophyllene oxide. Data are recorded as mean ± SEM. Differences were assessed by Dunnett’s multiple comparisons test and one-way ANOVA, *P < 0.05 vs MC, ***P < 0.001 vs MC, ****P < 0.0001 vs MC. (n = 6)