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Table 3 Dose-dependent activities of the three extracts of H. zeyheri on nitric oxide production inhibition and cell viability in RAW 246 mouse macrophages

From: In vitro antioxidant activity of crude extracts of Harpagophytum zeyheri and their anti-inflammatory and cytotoxicity activity compared with diclofenac

 

Concentration

Ethyl acetate

Ethanol

Water

Diclofenac

Quercetin

NO

100

62.84 ± 2.66a

53.87 ± 2.56b

27.01 ± 4.23c

68.26 ± 0.81a

69.05 ± 1.46a

50

41.68 ± 3.22a

29.34 ± 2.05b

9.24 ± 2.05c

65.31 ± 0.31a

68.59 ± 0.51a

25

24.67 ± 5.81a

17.92 ± 5.73b

8.03 ± 3.29c

60.09 ± 1.15a

57.27 ± 0.98a

12.5

14.45 ± 7.48a

14.10 ± 6.39a

7.38 ± 5.63b

49.77 ± 1.08c

40.62 ± 0.01c

Cell viability

100

60.65 ± 3.02a

85.90 ± 4.26a

102.97 ± 3.40a

1.12 ± 0.38b

27.97 ± 2.08c

50

90.91 ± 5.85a

96.68 ± 0.73a

111.17 ± 4.75a

2.98 ± 0.02b

34.72 ± 0.17c

25

88.95 ± 3.50a

96.72 ± 1.33a

90.79 ± 3.16a

7.57 ± 1.16b

59.15 ± 6.52a

12.5

89.98 ± 6.56a

98.32 ± 3.48a

95.95 ± 4.26a

15.57 ± 1.09b

86.98 ± 0.03a

  1. Values with different superscript letters in each row are significantly different at p < 0.05