Table 2 Pharmacokinetic parameters of madecassoside and asiaticoside, a main component of ECa 233. Data are shown as mean ± SD (n = 6)

C_max (μg/L)

N/A

147.84 ± 62.82

N/A

121.24 ± 113.32

T_max (h)

N/A

4.00 ± 2.45

N/A

0.50 ± 1.59

AUC_0-t (μg.h/L)

7588.69 ± 12,144.79

1591.66 ± 1430.06

8575.63 ± 3238.74

1307.35 ± 878.01

AUC_0-inf (μg.h/L)

7605.43 ± 12,142.80

1797.82 ± 1324.85

8691.56 ± 3330.53

1377.78 ± 882.71

MRT (h)

0.74 ± 0.31

8.80 ± 4.85

0.65 ± 0.18

6.41 ± 3.56

Vd (L/kg)

3.27 ± 3.91

284.78 ± 229.02

3.25 ± 2.22

189.68 ± 120.78

CL (L/h/kg)

2.25 ± 1.66

35.48 ± 26.99

0.67 ± 0.31

57.83.17 ± 47.04

T_1/2 (h)

0.98 ± 0.56

6.48 ± 6.18

4.50 ± 3.76

3.49 ± 2.19

Bioavailability (%)

N/A

2.36

N/A

1.58