Table 1 Physical appearance and biochemical profiles of pre-dose vs. post-dose. Data are shown as mean ± SD (n = 6; *P < 0.05)
| Compounds | Route | Physical appearance | Creatinine (mg/dL) | AST (U/L) | ALT (U/L) | ||||
|---|---|---|---|---|---|---|---|---|---|
|
Pre-dose (0 h) |
Post-dose (24 h) |
Pre-dose (0 h) |
Post-dose (24 h) |
Pre-dose (0 h) |
Post-dose (24 h) |
Pre-dose (0 h) |
Post-dose (24 h) | ||
| Asiaticoside |
IV 4 mg/kg | Normal | Normal | 0.60 ± 0.03 | 0.61 ± 0.04 | 42.40 ± 14.54 | 54.80 ± 9.20 | 26.80 ± 3.83 | 27.40 ± 5.32 |
| Madecassoside |
IV 5 mg/kg | Normal | Normal | 0.64 ± 0.04 | 0.67 ± 0.05 | 46.20 ± 4.87 | 63.20 ± 16.81 | 23.80 ± 2.59 | 24.00 ± 4.85 |
| ECa 233 |
PO 100 mg/kg | Normal | Normal | 0.61 ± 0.02 | 0.64 ± 0.01 | 45.02 ± 7.12 | 61.80 ± 15.69 | 24.80 ± 4.15 | 27.60 ± 6.11 |