Fig. 4

Indicative skin severity data of AD-like skin lesions and treatment effect by ROCEN in mice. A skin severity score of relative time points indicated a significant dermatitis healing by topical ROCEN rather than Beta in AD mice. The severity score was achieved by the sum of the relative dermatitis data (a’ (excoriation/erosion), b’ (scarring/dryness), c’ (edema), and d’ (erythema/ hemorrhage) scores) at 5 periods of experiment. B. Macroscopic features indicate that Oxa administration causes severe AD lesions at the different time intervals while ROCEN and Beta treatments recovered the lesion progress in mice. All data represented by mean ± SEM. A, B, C, D: treated groups compared with Oxa group. a, b, c, d: Oxa group compared with control group. 1, 2, 3, 4: ROCEN group compared with Beta group. Aa1; p<0.05, Bb2; p<0.01, Cc3; p<0.001, Dd4; p<0.0001