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Table 3 Binding energy (kcal/mol) and RMSD of three components of Epimedium and target proteins

From: Molecular mechanism of Epicedium treatment for depression based on network pharmacology and molecular docking technology

parameter

Estimated Free Energy of Binding

RMSD

receptor

IL6

VEGFA

AKT1

EGF

IL6

VEGFA

AKT1

EGF

ligand

luteolin

-5.48

-6.74

-6.95

-7.33

0.062

0.063

0.067

0.066

quercetin

-5.2

-7.31

-6.95

-6.3

1.165

1.166

1.17

1.17

kaempferol

-5.9

-6.85

-6.82

-6.49

0.064

0.066

0.069

0.069

fluoxetine

-4.77

-5.11

-5.35

-5.71

0.653

0.632

0.643

0.627